Primary biliary cirrhosis (PBC) is a chronic liver disease characterized by the progressive destruction of the small bile ducts. A letter to the editor highlights that the association between PBC and celiac disease should be more clearly emphasized. The prevalence of celiac disease in PBC patients is 10 times higher than in the general population. Additionally, a study found that the incidence of PBC in celiac disease patients is 27.6. Therefore, clinicians should systematically screen for celiac disease in PBC patients. Symptoms of PBC, such as osteoporosis, asthenia, and liver anomalies, may improve with a gluten-free diet in patients with celiac disease. Screening for both diseases is simplified by the availability of sensitive and specific markers. Xavier Roblin and Bruno Bonaz, both doctors from Grenoble University, France, emphasize the importance of this association. They note that early detection and management of celiac disease in PBC patients can lead to better outcomes. The authors reference two studies supporting their claims: one by Dickey et al. (1997) and another by Sorensen et al. (1999). The letter underscores the need for increased awareness of the link between PBC and celiac disease in clinical practice.Primary biliary cirrhosis (PBC) is a chronic liver disease characterized by the progressive destruction of the small bile ducts. A letter to the editor highlights that the association between PBC and celiac disease should be more clearly emphasized. The prevalence of celiac disease in PBC patients is 10 times higher than in the general population. Additionally, a study found that the incidence of PBC in celiac disease patients is 27.6. Therefore, clinicians should systematically screen for celiac disease in PBC patients. Symptoms of PBC, such as osteoporosis, asthenia, and liver anomalies, may improve with a gluten-free diet in patients with celiac disease. Screening for both diseases is simplified by the availability of sensitive and specific markers. Xavier Roblin and Bruno Bonaz, both doctors from Grenoble University, France, emphasize the importance of this association. They note that early detection and management of celiac disease in PBC patients can lead to better outcomes. The authors reference two studies supporting their claims: one by Dickey et al. (1997) and another by Sorensen et al. (1999). The letter underscores the need for increased awareness of the link between PBC and celiac disease in clinical practice.