Probiotics have emerged as promising agents in wound healing due to their anti-pathogenic, antibiofilm, and immunomodulatory properties. They can be administered orally or topically and have shown significant efficacy in various wound types, including chronic wounds, surgical wounds, diabetic foot ulcers, and burns. Probiotics inhibit the growth of pathogenic bacteria, disrupt biofilms, and modulate the immune response, thereby accelerating wound healing. Oral probiotics improve systemic health by enhancing mineral absorption, reducing inflammation, and regulating the microbiota. Topical probiotics directly act on the wound site, promoting tissue repair and reducing bacterial colonization. Recent studies have also explored the use of wound dressings embedded with probiotics and prebiotics, which offer enhanced antibacterial and immunomodulatory effects. These dressings are made from biopolymers and hydrogels, providing barriers and promoting healing. The combination of probiotics and prebiotics in wound dressings has shown potential in preventing and treating resistant wound infections. Overall, probiotics represent a valuable adjunct in wound management, offering a natural and effective approach to combat microbial infections and promote wound healing.Probiotics have emerged as promising agents in wound healing due to their anti-pathogenic, antibiofilm, and immunomodulatory properties. They can be administered orally or topically and have shown significant efficacy in various wound types, including chronic wounds, surgical wounds, diabetic foot ulcers, and burns. Probiotics inhibit the growth of pathogenic bacteria, disrupt biofilms, and modulate the immune response, thereby accelerating wound healing. Oral probiotics improve systemic health by enhancing mineral absorption, reducing inflammation, and regulating the microbiota. Topical probiotics directly act on the wound site, promoting tissue repair and reducing bacterial colonization. Recent studies have also explored the use of wound dressings embedded with probiotics and prebiotics, which offer enhanced antibacterial and immunomodulatory effects. These dressings are made from biopolymers and hydrogels, providing barriers and promoting healing. The combination of probiotics and prebiotics in wound dressings has shown potential in preventing and treating resistant wound infections. Overall, probiotics represent a valuable adjunct in wound management, offering a natural and effective approach to combat microbial infections and promote wound healing.