Probiotics have shown potential in wound healing by improving tissue repair, reducing infection, and promoting healing through their anti-pathogenic, antibiofilm, and immunomodulatory effects. This review discusses the role of oral and topical probiotics in wound management and their potential in wound dressings embedded with pre- and probiotics. Wound healing involves several phases: hemostasis, inflammation, proliferation, and remodeling. Probiotics can inhibit pathogen growth, compete for nutrients, and modulate immune responses, aiding in wound healing. Oral and topical probiotics have been studied in various clinical trials and in vitro models, demonstrating their ability to enhance tissue repair and reduce inflammation. Probiotics such as Lactobacillus and Bifidobacterium species have shown effectiveness in treating conditions like diabetic foot ulcers, surgical wounds, and burns. Topical probiotics have also been investigated for their antimicrobial and immunomodulatory properties. Probiotic-containing wound dressings and prebiotic combinations have been explored for their potential to improve wound healing and prevent infections. These formulations may offer a promising alternative to traditional antibiotics, especially in the context of antibiotic resistance. The review highlights the need for further research to optimize probiotic formulations and their application in wound healing.Probiotics have shown potential in wound healing by improving tissue repair, reducing infection, and promoting healing through their anti-pathogenic, antibiofilm, and immunomodulatory effects. This review discusses the role of oral and topical probiotics in wound management and their potential in wound dressings embedded with pre- and probiotics. Wound healing involves several phases: hemostasis, inflammation, proliferation, and remodeling. Probiotics can inhibit pathogen growth, compete for nutrients, and modulate immune responses, aiding in wound healing. Oral and topical probiotics have been studied in various clinical trials and in vitro models, demonstrating their ability to enhance tissue repair and reduce inflammation. Probiotics such as Lactobacillus and Bifidobacterium species have shown effectiveness in treating conditions like diabetic foot ulcers, surgical wounds, and burns. Topical probiotics have also been investigated for their antimicrobial and immunomodulatory properties. Probiotic-containing wound dressings and prebiotic combinations have been explored for their potential to improve wound healing and prevent infections. These formulations may offer a promising alternative to traditional antibiotics, especially in the context of antibiotic resistance. The review highlights the need for further research to optimize probiotic formulations and their application in wound healing.