This systematic review and meta-analysis evaluates the associations between problem-solving skills training (PSST) and psychosocial outcomes in parents of children with chronic health conditions (CHCs). The study included 23 randomized clinical trials (RCTs) involving 3,141 parents, with 21 eligible for meta-analysis. PSST was found to significantly improve parental outcomes, including problem-solving skills, depression, distress, posttraumatic stress, parenting stress, and quality of life (QOL). For children, PSST was associated with better QOL, fewer mental problems, and less parent-child conflict. Subgroup analyses showed that PSST was more effective for parents of children aged 10 years or younger or newly diagnosed with CHCs. Online delivery of PSST yielded larger effects on most outcomes compared to face-to-face interventions. The findings suggest that PSST can enhance the psychosocial well-being of parents, children, and families of children with CHCs, highlighting its potential as an effective intervention. However, further high-quality RCTs with longer follow-up times and exploration of physical and clinical outcomes are needed to generate robust evidence.This systematic review and meta-analysis evaluates the associations between problem-solving skills training (PSST) and psychosocial outcomes in parents of children with chronic health conditions (CHCs). The study included 23 randomized clinical trials (RCTs) involving 3,141 parents, with 21 eligible for meta-analysis. PSST was found to significantly improve parental outcomes, including problem-solving skills, depression, distress, posttraumatic stress, parenting stress, and quality of life (QOL). For children, PSST was associated with better QOL, fewer mental problems, and less parent-child conflict. Subgroup analyses showed that PSST was more effective for parents of children aged 10 years or younger or newly diagnosed with CHCs. Online delivery of PSST yielded larger effects on most outcomes compared to face-to-face interventions. The findings suggest that PSST can enhance the psychosocial well-being of parents, children, and families of children with CHCs, highlighting its potential as an effective intervention. However, further high-quality RCTs with longer follow-up times and exploration of physical and clinical outcomes are needed to generate robust evidence.