This systematic review and meta-analysis evaluated the effects of problem-solving skills training (PSST) on parental, pediatric, and family psychosocial outcomes for parents of children with chronic health conditions (CHCs). The study included 23 randomized clinical trials (RCTs) involving 3141 parents, with 21 eligible for meta-analysis. PSST was associated with significant improvements in parental outcomes, including problem-solving skills, depression, distress, posttraumatic stress, parenting stress, and quality of life (QOL). For children, PSST was linked to better QOL, fewer mental problems, and less parent-child conflict. Subgroup analyses showed that PSST was more effective for parents of children aged 10 years or younger or who were newly diagnosed with a CHC. Online delivery of PSST was associated with significant improvements in most outcomes. The findings suggest that PSST can improve psychosocial well-being for parents, their children, and their families. However, further high-quality RCTs with longer follow-up periods and exploring physical and clinical outcomes are needed to generate adequate evidence. The study highlights the importance of PSST as an active component of psychosocial interventions for parents of children with CHCs.This systematic review and meta-analysis evaluated the effects of problem-solving skills training (PSST) on parental, pediatric, and family psychosocial outcomes for parents of children with chronic health conditions (CHCs). The study included 23 randomized clinical trials (RCTs) involving 3141 parents, with 21 eligible for meta-analysis. PSST was associated with significant improvements in parental outcomes, including problem-solving skills, depression, distress, posttraumatic stress, parenting stress, and quality of life (QOL). For children, PSST was linked to better QOL, fewer mental problems, and less parent-child conflict. Subgroup analyses showed that PSST was more effective for parents of children aged 10 years or younger or who were newly diagnosed with a CHC. Online delivery of PSST was associated with significant improvements in most outcomes. The findings suggest that PSST can improve psychosocial well-being for parents, their children, and their families. However, further high-quality RCTs with longer follow-up periods and exploring physical and clinical outcomes are needed to generate adequate evidence. The study highlights the importance of PSST as an active component of psychosocial interventions for parents of children with CHCs.