A 2024 review of gastric cancer (GC) highlights advancements in diagnosis, prognosis, and treatment. Surgery remains the primary treatment, but immunotherapy and targeted therapies are increasingly important. Post-surgery, a multidisciplinary approach involving nutritionists and psychologists is essential. New diagnostic methods, such as spectral CT and DWI, improve prediction of neoadjuvant chemotherapy response. Biomarkers like ALDH3B1 and NY-ESO-1 are being explored for better prognosis and treatment. Immunotherapy, including checkpoint inhibitors, shows promise, while plant extracts and novel therapies like silver nanoparticles are being tested. Chemotherapy combinations, such as nivolumab with oxaliplatin, are effective for advanced GC. Surgical techniques, including laparoscopic and robotic approaches, are improving outcomes. Therapeutic targets like PFDN5 and IGF2BP3 are being studied. Future directions include liquid biopsies and machine learning models for early detection and personalized treatment. Funding for research is crucial due to the high mortality rate of GC.A 2024 review of gastric cancer (GC) highlights advancements in diagnosis, prognosis, and treatment. Surgery remains the primary treatment, but immunotherapy and targeted therapies are increasingly important. Post-surgery, a multidisciplinary approach involving nutritionists and psychologists is essential. New diagnostic methods, such as spectral CT and DWI, improve prediction of neoadjuvant chemotherapy response. Biomarkers like ALDH3B1 and NY-ESO-1 are being explored for better prognosis and treatment. Immunotherapy, including checkpoint inhibitors, shows promise, while plant extracts and novel therapies like silver nanoparticles are being tested. Chemotherapy combinations, such as nivolumab with oxaliplatin, are effective for advanced GC. Surgical techniques, including laparoscopic and robotic approaches, are improving outcomes. Therapeutic targets like PFDN5 and IGF2BP3 are being studied. Future directions include liquid biopsies and machine learning models for early detection and personalized treatment. Funding for research is crucial due to the high mortality rate of GC.