Elsevier established a free COVID-19 resource center in January 2020, offering information in English and Mandarin. The center grants free access to its research in PubMed Central and other repositories. A study investigated the prognostic value of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin (PCT) in predicting mild and severe cases of COVID-19. The study included 140 patients, divided into mild (MG, n=107) and severe (SG, n=33) groups. IL-6, CRP, and PCT levels were measured on admission. Results showed that higher levels of IL-6 and CRP were more common in severe cases. The area under the receiver operating characteristic curve (AUROC) for these markers ranged from 0.8 to 0.9, indicating high diagnostic value. The optimal thresholds were 32.1 pg/mL for IL-6, 41.8 mg/L for CRP, and 0.07 ng/mL for PCT. Cox proportional hazard models confirmed that IL-6 and CRP were independent predictors of disease severity. Patients with IL-6 > 32.1 pg/mL or CRP > 41.8 mg/L were more likely to have severe complications. The study concluded that serum levels of IL-6 and CRP can effectively assess disease severity and predict outcomes in COVID-19 patients. PCT showed lower predictive value due to a small sample size. The study had limitations, including a small sample size and limited clinical data. The authors emphasized the importance of IL-6 and CRP in predicting disease severity. The study was supported by the National Natural Science Foundation of China and the Medjaden Academy & Research Foundation for Young Scientists. The authors declared no competing interests.Elsevier established a free COVID-19 resource center in January 2020, offering information in English and Mandarin. The center grants free access to its research in PubMed Central and other repositories. A study investigated the prognostic value of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin (PCT) in predicting mild and severe cases of COVID-19. The study included 140 patients, divided into mild (MG, n=107) and severe (SG, n=33) groups. IL-6, CRP, and PCT levels were measured on admission. Results showed that higher levels of IL-6 and CRP were more common in severe cases. The area under the receiver operating characteristic curve (AUROC) for these markers ranged from 0.8 to 0.9, indicating high diagnostic value. The optimal thresholds were 32.1 pg/mL for IL-6, 41.8 mg/L for CRP, and 0.07 ng/mL for PCT. Cox proportional hazard models confirmed that IL-6 and CRP were independent predictors of disease severity. Patients with IL-6 > 32.1 pg/mL or CRP > 41.8 mg/L were more likely to have severe complications. The study concluded that serum levels of IL-6 and CRP can effectively assess disease severity and predict outcomes in COVID-19 patients. PCT showed lower predictive value due to a small sample size. The study had limitations, including a small sample size and limited clinical data. The authors emphasized the importance of IL-6 and CRP in predicting disease severity. The study was supported by the National Natural Science Foundation of China and the Medjaden Academy & Research Foundation for Young Scientists. The authors declared no competing interests.