Chronic diabetic wounds are prone to develop diabetic foot ulcers due to severe hypoxia, excessive reactive oxygen species (ROS), a complex inflammatory microenvironment, and potential bacterial infections. This study develops a programmed treatment strategy using live Haematococcus (HEA) to promote chronic wound healing in diabetes. By modulating light intensity, HEA can perform various functions such as antibacterial activity, oxygen supply, ROS scavenging, and immune regulation. Under high light intensity, green HEA (GHEA) mediates wound surface disinfection, while decreasing light intensity allows GHEA to continuously produce oxygen, resolving hypoxia and promoting vascular regeneration. Continuous light irradiation induces astaxanthin (AST) accumulation in HEA cells, transforming them into red HEA (RHEA) and enhancing their ability to modulate the wound microenvironment. The living HEA hydrogel sterilizes the wound, enhances cell proliferation and migration, and promotes neoangiogenesis, improving infected diabetic wound healing in female mice. The study demonstrates the potential of a simple hydrogel dressing loaded with multifunctional materials or drugs to address the challenges of chronic diabetic wounds, including hypoxia, ROS, and bacterial infection.Chronic diabetic wounds are prone to develop diabetic foot ulcers due to severe hypoxia, excessive reactive oxygen species (ROS), a complex inflammatory microenvironment, and potential bacterial infections. This study develops a programmed treatment strategy using live Haematococcus (HEA) to promote chronic wound healing in diabetes. By modulating light intensity, HEA can perform various functions such as antibacterial activity, oxygen supply, ROS scavenging, and immune regulation. Under high light intensity, green HEA (GHEA) mediates wound surface disinfection, while decreasing light intensity allows GHEA to continuously produce oxygen, resolving hypoxia and promoting vascular regeneration. Continuous light irradiation induces astaxanthin (AST) accumulation in HEA cells, transforming them into red HEA (RHEA) and enhancing their ability to modulate the wound microenvironment. The living HEA hydrogel sterilizes the wound, enhances cell proliferation and migration, and promotes neoangiogenesis, improving infected diabetic wound healing in female mice. The study demonstrates the potential of a simple hydrogel dressing loaded with multifunctional materials or drugs to address the challenges of chronic diabetic wounds, including hypoxia, ROS, and bacterial infection.