The article "Progress in Nonaqueous Molecular Uranium Chemistry: Where to Next?" by Stephen T. Liddle provides a comprehensive overview of the advancements in nonaqueous uranium chemistry over the past four decades. The author reflects on a 1988 conference presentation slide that outlined key targets for synthetic actinide chemistry, including CO and related π-acid ligand complexes, alkylidenes, carbynes, carbidos, imidos, terminal nitrides, homoleptic polyalkyl- and -alkoxides, and U-U bonds. The article highlights the challenges and progress in achieving these targets, such as the synthesis of structurally authenticated uranium carbonyls, the development of uranium alkylidenes, and the isolation of homoleptic uranium polyalkyl complexes. It also discusses the importance of ligand-metal complementarity in enabling new structural motifs and reactivities. The article concludes by reflecting on the broad range of advances achieved and suggests future directions, emphasizing the need for continued exploration and innovation in the field.The article "Progress in Nonaqueous Molecular Uranium Chemistry: Where to Next?" by Stephen T. Liddle provides a comprehensive overview of the advancements in nonaqueous uranium chemistry over the past four decades. The author reflects on a 1988 conference presentation slide that outlined key targets for synthetic actinide chemistry, including CO and related π-acid ligand complexes, alkylidenes, carbynes, carbidos, imidos, terminal nitrides, homoleptic polyalkyl- and -alkoxides, and U-U bonds. The article highlights the challenges and progress in achieving these targets, such as the synthesis of structurally authenticated uranium carbonyls, the development of uranium alkylidenes, and the isolation of homoleptic uranium polyalkyl complexes. It also discusses the importance of ligand-metal complementarity in enabling new structural motifs and reactivities. The article concludes by reflecting on the broad range of advances achieved and suggests future directions, emphasizing the need for continued exploration and innovation in the field.