The article discusses recent progress in nonaqueous uranium chemistry, focusing on the development of uranium complexes with various ligands and bonding motifs. It highlights the importance of ligand-metal complementarity in enabling new uranium chemistry. The article reviews the historical context, including the 1988 conference presentation that set the stage for future research. It covers the synthesis and characterization of uranium complexes with CO and related π-acid ligands, alkylidenes, carbynes, carbidos, imidos, terminal nitrides, homoleptic polyalkyls, -alkoxides, and -aryloxides, as well as uranium-uranium bonds. The article also discusses the development of uranium–CO₂ chemistry and the synthesis of uranium–N₂ complexes, which have implications for nitrogen fixation. The article emphasizes the unique properties of uranium, including its ability to activate nitrogen and its variable bonding behavior. It also highlights the progress in uranium alkyl and aryl complexes, as well as the challenges in isolating uranium-uranium bonds. The article concludes by noting that while many targets from the 1988 conference have been achieved, there are still many challenges and opportunities for further research in uranium chemistry.The article discusses recent progress in nonaqueous uranium chemistry, focusing on the development of uranium complexes with various ligands and bonding motifs. It highlights the importance of ligand-metal complementarity in enabling new uranium chemistry. The article reviews the historical context, including the 1988 conference presentation that set the stage for future research. It covers the synthesis and characterization of uranium complexes with CO and related π-acid ligands, alkylidenes, carbynes, carbidos, imidos, terminal nitrides, homoleptic polyalkyls, -alkoxides, and -aryloxides, as well as uranium-uranium bonds. The article also discusses the development of uranium–CO₂ chemistry and the synthesis of uranium–N₂ complexes, which have implications for nitrogen fixation. The article emphasizes the unique properties of uranium, including its ability to activate nitrogen and its variable bonding behavior. It also highlights the progress in uranium alkyl and aryl complexes, as well as the challenges in isolating uranium-uranium bonds. The article concludes by noting that while many targets from the 1988 conference have been achieved, there are still many challenges and opportunities for further research in uranium chemistry.