The skin, the largest organ of the body, acts as a protective barrier against external factors. Chronic wounds, affecting millions worldwide, are associated with significant morbidity and reduced quality of life. Oxidative stress, triggered by overproduction of reactive oxygen species (ROS), is a key factor in delayed wound healing, impairing cellular components, delaying inflammation, and inhibiting new blood vessel formation. Antioxidants, including non-enzymatic antioxidants like ascorbic acid (vitamin C), melatonin, glutathione, alpha-tocopherol (vitamin E), ubiquinone (coenzyme Q10), carotenoids, alpha-lipoic acid, flavonoids, and polyphenols, play crucial roles in protecting against oxidative damage and promoting wound healing. Hydrogels, with their 3D structure, good permeability, and biocompatibility, are ideal for wound healing due to their ability to provide a moist environment and support tissue recovery. Natural polymers such as collagen, alginate, hyaluronic acid, chitosan, and gelatin, as well as synthetic polymers like poly(ethylene glycol) (PEG), poly(vinyl alcohol) (PVA), and poly(lactic acid) (PLA), are commonly used in hydrogel development. These hydrogels can be loaded with antioxidants to enhance their therapeutic effects. For example, ascorbic acid promotes collagen synthesis and reduces inflammation, while alpha-tocopherol scavenges free radicals and protects cell membranes. Hydrogels incorporating antioxidants have shown promise in improving wound healing outcomes, making them valuable tools in the management of chronic wounds.The skin, the largest organ of the body, acts as a protective barrier against external factors. Chronic wounds, affecting millions worldwide, are associated with significant morbidity and reduced quality of life. Oxidative stress, triggered by overproduction of reactive oxygen species (ROS), is a key factor in delayed wound healing, impairing cellular components, delaying inflammation, and inhibiting new blood vessel formation. Antioxidants, including non-enzymatic antioxidants like ascorbic acid (vitamin C), melatonin, glutathione, alpha-tocopherol (vitamin E), ubiquinone (coenzyme Q10), carotenoids, alpha-lipoic acid, flavonoids, and polyphenols, play crucial roles in protecting against oxidative damage and promoting wound healing. Hydrogels, with their 3D structure, good permeability, and biocompatibility, are ideal for wound healing due to their ability to provide a moist environment and support tissue recovery. Natural polymers such as collagen, alginate, hyaluronic acid, chitosan, and gelatin, as well as synthetic polymers like poly(ethylene glycol) (PEG), poly(vinyl alcohol) (PVA), and poly(lactic acid) (PLA), are commonly used in hydrogel development. These hydrogels can be loaded with antioxidants to enhance their therapeutic effects. For example, ascorbic acid promotes collagen synthesis and reduces inflammation, while alpha-tocopherol scavenges free radicals and protects cell membranes. Hydrogels incorporating antioxidants have shown promise in improving wound healing outcomes, making them valuable tools in the management of chronic wounds.