Heyndrickxia coagulans (Bacillus coagulans) is a novel probiotic species with significant potential in promoting human health. It is a Gram-positive, spore-forming bacterium that can survive in harsh environments, including gastric acid, and germinate in the small intestine. Unlike common probiotics, H. coagulans produces spores that provide high resistance to adverse conditions, allowing it to survive and germinate in the gut. It is non-toxic, non-pathogenic, and does not produce toxins, making it safe for consumption. H. coagulans can enhance gut microbiota balance, improve immunity, and stimulate growth. It also has antibacterial properties and can inhibit harmful bacteria, contributing to the prevention of dysbacteriosis. Its ability to produce short-chain fatty acids like butyric acid helps maintain intestinal barrier function and promotes the production of mucin, which protects the intestinal epithelium. H. coagulans is used in various applications, including aquaculture as an alternative to antibiotics, and in the food and pharmaceutical industries as a probiotic supplement. It can regulate the body's physical and chemical properties, promoting the growth of beneficial bacteria and inhibiting harmful ones, thus improving the immune system. Genomic studies have shown that H. coagulans lacks mobile genetic elements and has a stable genome, reducing the risk of genetic transfer and ensuring a non-pathogenic phenotype. It also has a low risk of antibiotic resistance due to the absence of mobile elements around resistance genes. H. coagulans exhibits strong stress resistance, including tolerance to high temperatures, acidity, and bile salts. It can inhibit harmful bacteria through competitive exclusion and colonization resistance, and promote the growth of beneficial bacteria like Lactobacillus and Bifidobacterium. It produces metabolites such as L-lactic acid, which lower the pH of the gastrointestinal tract, creating a favorable environment for anaerobic bacteria. H. coagulans also secretes adhesion proteins that facilitate colonization in the gut and reduce pathogenic adhesion. H. coagulans has various probiotic functions, including improving gastrointestinal health, enhancing exercise performance, aiding in weight management, modulating the immune system, and preventing diseases. It can also contribute to beauty and anti-aging by reducing oxidative stress and promoting skin cell renewal. It has potential in cancer prevention and can alleviate allergy symptoms. H. coagulans is used in clinical applications to treat gastrointestinal disorders, dental caries, vaginitis, rheumatoid arthritis, heavy metal toxicity, and hyperlipidemia. It is also effective in maintaining intestinal health, protecting the stomach, and stabilizing the oral, reproductive, and dermal systems. It can help prevent and treat infections such as bacterial vaginosis and candida-related infections. H. coagulans has immunomodulatory effects, enhancing mucosal immunity and regulating immuneHeyndrickxia coagulans (Bacillus coagulans) is a novel probiotic species with significant potential in promoting human health. It is a Gram-positive, spore-forming bacterium that can survive in harsh environments, including gastric acid, and germinate in the small intestine. Unlike common probiotics, H. coagulans produces spores that provide high resistance to adverse conditions, allowing it to survive and germinate in the gut. It is non-toxic, non-pathogenic, and does not produce toxins, making it safe for consumption. H. coagulans can enhance gut microbiota balance, improve immunity, and stimulate growth. It also has antibacterial properties and can inhibit harmful bacteria, contributing to the prevention of dysbacteriosis. Its ability to produce short-chain fatty acids like butyric acid helps maintain intestinal barrier function and promotes the production of mucin, which protects the intestinal epithelium. H. coagulans is used in various applications, including aquaculture as an alternative to antibiotics, and in the food and pharmaceutical industries as a probiotic supplement. It can regulate the body's physical and chemical properties, promoting the growth of beneficial bacteria and inhibiting harmful ones, thus improving the immune system. Genomic studies have shown that H. coagulans lacks mobile genetic elements and has a stable genome, reducing the risk of genetic transfer and ensuring a non-pathogenic phenotype. It also has a low risk of antibiotic resistance due to the absence of mobile elements around resistance genes. H. coagulans exhibits strong stress resistance, including tolerance to high temperatures, acidity, and bile salts. It can inhibit harmful bacteria through competitive exclusion and colonization resistance, and promote the growth of beneficial bacteria like Lactobacillus and Bifidobacterium. It produces metabolites such as L-lactic acid, which lower the pH of the gastrointestinal tract, creating a favorable environment for anaerobic bacteria. H. coagulans also secretes adhesion proteins that facilitate colonization in the gut and reduce pathogenic adhesion. H. coagulans has various probiotic functions, including improving gastrointestinal health, enhancing exercise performance, aiding in weight management, modulating the immune system, and preventing diseases. It can also contribute to beauty and anti-aging by reducing oxidative stress and promoting skin cell renewal. It has potential in cancer prevention and can alleviate allergy symptoms. H. coagulans is used in clinical applications to treat gastrointestinal disorders, dental caries, vaginitis, rheumatoid arthritis, heavy metal toxicity, and hyperlipidemia. It is also effective in maintaining intestinal health, protecting the stomach, and stabilizing the oral, reproductive, and dermal systems. It can help prevent and treat infections such as bacterial vaginosis and candida-related infections. H. coagulans has immunomodulatory effects, enhancing mucosal immunity and regulating immune