The article discusses the probiotic properties and mechanisms of *Heyndrickxia coagulans* (*H. coagulans*), a novel probiotic species with potential health benefits. *H. coagulans* is a Gram-positive, facultatively anaerobic bacterium that produces spores, providing high resistance to adverse conditions. It can ferment various substrates and produce acid without gas. The article outlines the requirements for a substance to be classified as a probiotic and addresses the assessment of strains with probiotic properties. *H. coagulans* is known for its ability to maintain the balance of the intestinal microbiome, enhance metabolite production, increase immunity, and stimulate growth. It does not have negative antibiotic effects and helps maintain the natural flora in animals. The article also highlights the genomic insights and secondary metabolite potential of *H. coagulans*, including its stress resistance, inhibitory properties, and promotion of beneficial bacteria. The probiotic effects of *H. coagulans* are detailed, including its role in gastrointestinal conditioning, exercise performance, weight management, immune modulation, systemic well-being, and disease prevention. It has been shown to improve gut health, enhance exercise performance, and support immune function. The article also discusses the clinical applications of *H. coagulans*, such as in the treatment of gastrointestinal disorders, dental caries, vaginitis, rheumatoid arthritis, and heavy metal toxicity. The article concludes by summarizing the probiotic properties and applications of *H. coagulans*, emphasizing its potential as a promising probiotic for treating intestinal illnesses. It highlights the need for further genetic research to clarify the molecular mechanisms behind its beneficial effects.The article discusses the probiotic properties and mechanisms of *Heyndrickxia coagulans* (*H. coagulans*), a novel probiotic species with potential health benefits. *H. coagulans* is a Gram-positive, facultatively anaerobic bacterium that produces spores, providing high resistance to adverse conditions. It can ferment various substrates and produce acid without gas. The article outlines the requirements for a substance to be classified as a probiotic and addresses the assessment of strains with probiotic properties. *H. coagulans* is known for its ability to maintain the balance of the intestinal microbiome, enhance metabolite production, increase immunity, and stimulate growth. It does not have negative antibiotic effects and helps maintain the natural flora in animals. The article also highlights the genomic insights and secondary metabolite potential of *H. coagulans*, including its stress resistance, inhibitory properties, and promotion of beneficial bacteria. The probiotic effects of *H. coagulans* are detailed, including its role in gastrointestinal conditioning, exercise performance, weight management, immune modulation, systemic well-being, and disease prevention. It has been shown to improve gut health, enhance exercise performance, and support immune function. The article also discusses the clinical applications of *H. coagulans*, such as in the treatment of gastrointestinal disorders, dental caries, vaginitis, rheumatoid arthritis, and heavy metal toxicity. The article concludes by summarizing the probiotic properties and applications of *H. coagulans*, emphasizing its potential as a promising probiotic for treating intestinal illnesses. It highlights the need for further genetic research to clarify the molecular mechanisms behind its beneficial effects.