This study investigates the blood coagulation function of patients with SARS-CoV-2 infection. The research included 94 confirmed SARS-CoV-2-infected patients and 40 healthy controls. Key findings include: 1. **Antithrombin (AT) Levels**: Patients had significantly lower AT levels compared to the control group (p < 0.001). 2. **Fibrin/Fibrinogen Degradation Products (FDP) and Fibrinogen (FIB) Levels**: Both D-dimer and FDP levels were significantly higher in patients compared to controls (p < 0.001). FIB levels were also higher in patients (p < 0.001). 3. **Prothrombin Time Activity (PT-act)**: PT-act was lower in patients compared to controls (p < 0.001). 4. **APTT, PT, PT-INR, and TT**: No significant differences were observed between patients and controls in these parameters (p > 0.05). 5. **Subgroup Analysis**: In patients with severe and critical disease, D-dimer and FDP levels were significantly higher compared to mild cases and controls (p < 0.05). The study suggests that routine monitoring of coagulation parameters may be useful for early diagnosis and predicting disease progression in COVID-19 patients. The findings support the idea that consumptive coagulopathy, particularly disseminated intravascular coagulation (DIC), may occur in SARS-CoV-2 infection and influence clinical outcomes.This study investigates the blood coagulation function of patients with SARS-CoV-2 infection. The research included 94 confirmed SARS-CoV-2-infected patients and 40 healthy controls. Key findings include: 1. **Antithrombin (AT) Levels**: Patients had significantly lower AT levels compared to the control group (p < 0.001). 2. **Fibrin/Fibrinogen Degradation Products (FDP) and Fibrinogen (FIB) Levels**: Both D-dimer and FDP levels were significantly higher in patients compared to controls (p < 0.001). FIB levels were also higher in patients (p < 0.001). 3. **Prothrombin Time Activity (PT-act)**: PT-act was lower in patients compared to controls (p < 0.001). 4. **APTT, PT, PT-INR, and TT**: No significant differences were observed between patients and controls in these parameters (p > 0.05). 5. **Subgroup Analysis**: In patients with severe and critical disease, D-dimer and FDP levels were significantly higher compared to mild cases and controls (p < 0.05). The study suggests that routine monitoring of coagulation parameters may be useful for early diagnosis and predicting disease progression in COVID-19 patients. The findings support the idea that consumptive coagulopathy, particularly disseminated intravascular coagulation (DIC), may occur in SARS-CoV-2 infection and influence clinical outcomes.