The article reviews the recent advances in the research of prostaglandin E (PGE) receptors, focusing on the four subtypes (EP1, EP2, EP3, and EP4) and their multiple splicing isoforms. These receptors are G-protein-coupled receptors (GPCRs) that mediate various physiological and pathophysiological responses to PGE2. The biochemical properties, ligand binding characteristics, signal transduction pathways, tissue distribution, and cellular localization of each EP subtype are detailed. The article also discusses the regulation of EP gene expression by various stimuli and the roles of each subtype in processes such as inflammation, pain, and immune responses. Studies using knock-out mice deficient in each EP subtype have provided insights into the specific functions of these receptors, highlighting their versatility and importance in maintaining homeostasis and responding to various physiological and pathological conditions.The article reviews the recent advances in the research of prostaglandin E (PGE) receptors, focusing on the four subtypes (EP1, EP2, EP3, and EP4) and their multiple splicing isoforms. These receptors are G-protein-coupled receptors (GPCRs) that mediate various physiological and pathophysiological responses to PGE2. The biochemical properties, ligand binding characteristics, signal transduction pathways, tissue distribution, and cellular localization of each EP subtype are detailed. The article also discusses the regulation of EP gene expression by various stimuli and the roles of each subtype in processes such as inflammation, pain, and immune responses. Studies using knock-out mice deficient in each EP subtype have provided insights into the specific functions of these receptors, highlighting their versatility and importance in maintaining homeostasis and responding to various physiological and pathological conditions.