The article reviews the multifunctional role of protein kinase B (PKB), also known as c-Akt, in signaling pathways activated by phosphatidylinositol 3-kinase (PI-3K). PKB is activated by PI-3K-generated phosphoinositides, particularly PtdIns(3,4,5)P3, through its pleckstrin homology (PH) domain. This activation involves phosphorylation at two residues, Thr399 and Ser423, which relieve intermolecular inhibition and allow the kinase to dissociate from the membrane and modify its targets. PKB is involved in various cellular processes, including metabolic regulation, glucose transport, glycogen synthesis, glycolysis, and protein synthesis. It also plays a crucial role in anti-apoptotic signaling, protecting cells from apoptosis through mechanisms such as inhibiting caspases, inducing Bcl-2 expression, and regulating the cell cycle. The article discusses the mechanisms of PKB activation, its complexes with other proteins, and the tools used to modulate its activity. Additionally, it highlights the importance of PKB in cytokine-mediated cell survival and its potential role in controlling cell-cycle progression.The article reviews the multifunctional role of protein kinase B (PKB), also known as c-Akt, in signaling pathways activated by phosphatidylinositol 3-kinase (PI-3K). PKB is activated by PI-3K-generated phosphoinositides, particularly PtdIns(3,4,5)P3, through its pleckstrin homology (PH) domain. This activation involves phosphorylation at two residues, Thr399 and Ser423, which relieve intermolecular inhibition and allow the kinase to dissociate from the membrane and modify its targets. PKB is involved in various cellular processes, including metabolic regulation, glucose transport, glycogen synthesis, glycolysis, and protein synthesis. It also plays a crucial role in anti-apoptotic signaling, protecting cells from apoptosis through mechanisms such as inhibiting caspases, inducing Bcl-2 expression, and regulating the cell cycle. The article discusses the mechanisms of PKB activation, its complexes with other proteins, and the tools used to modulate its activity. Additionally, it highlights the importance of PKB in cytokine-mediated cell survival and its potential role in controlling cell-cycle progression.