The study by Husi et al. (2000) investigates the proteomic composition of NMDA receptor multiprotein complexes (NRC) isolated from mouse brain using mass spectrometry and immunoblotting. The NRC consists of 77 proteins, including receptor, adaptor, signaling, cytoskeletal, and novel proteins. Key findings include the association of NMDAR and metabotropic glutamate receptors with cadherins and L1 cell-adhesion molecules, and the presence of kinases, phosphatases, GTPase-activating proteins, and Ras effectors. The NRC is linked to learning and synaptic plasticity in rodents, with genetic or pharmacological interference affecting 15 and 22 proteins, respectively. Mutations in three human genes (NF1, Rsk-2, L1) associated with learning impairments suggest the NRC's role in human cognition. The study highlights the importance of the NRC in the induction phase of synaptic plasticity and its potential as a therapeutic target for learning and memory disorders.The study by Husi et al. (2000) investigates the proteomic composition of NMDA receptor multiprotein complexes (NRC) isolated from mouse brain using mass spectrometry and immunoblotting. The NRC consists of 77 proteins, including receptor, adaptor, signaling, cytoskeletal, and novel proteins. Key findings include the association of NMDAR and metabotropic glutamate receptors with cadherins and L1 cell-adhesion molecules, and the presence of kinases, phosphatases, GTPase-activating proteins, and Ras effectors. The NRC is linked to learning and synaptic plasticity in rodents, with genetic or pharmacological interference affecting 15 and 22 proteins, respectively. Mutations in three human genes (NF1, Rsk-2, L1) associated with learning impairments suggest the NRC's role in human cognition. The study highlights the importance of the NRC in the induction phase of synaptic plasticity and its potential as a therapeutic target for learning and memory disorders.