Proton pump inhibitors (PPIs) are widely used drugs linked to changes in the gut microbiome, increasing the risk of enteric infections like Clostridium difficile. A study analyzed the gut microbiome of 1815 individuals across three cohorts and found that PPI users had reduced bacterial diversity and altered microbiota, with increased levels of oral and potentially pathogenic bacteria. These changes were consistent across all cohorts and were more significant than those caused by antibiotics or other common drugs. PPI use was associated with a higher risk of infections due to changes in the gut microbiome that may promote pathogen colonization. The study highlights the need for healthcare professionals to consider the impact of PPIs on the gut microbiome, especially given their widespread use and the rising incidence of enteric infections. The findings suggest that PPIs may alter the gut microbiome in ways that increase susceptibility to infections, emphasizing the importance of monitoring and managing PPI use.Proton pump inhibitors (PPIs) are widely used drugs linked to changes in the gut microbiome, increasing the risk of enteric infections like Clostridium difficile. A study analyzed the gut microbiome of 1815 individuals across three cohorts and found that PPI users had reduced bacterial diversity and altered microbiota, with increased levels of oral and potentially pathogenic bacteria. These changes were consistent across all cohorts and were more significant than those caused by antibiotics or other common drugs. PPI use was associated with a higher risk of infections due to changes in the gut microbiome that may promote pathogen colonization. The study highlights the need for healthcare professionals to consider the impact of PPIs on the gut microbiome, especially given their widespread use and the rising incidence of enteric infections. The findings suggest that PPIs may alter the gut microbiome in ways that increase susceptibility to infections, emphasizing the importance of monitoring and managing PPI use.