Psoriasis is a common, chronic, and recurrent immune-mediated skin disease that can significantly impact the physical, emotional, and psychosocial well-being of affected patients. It is prevalent worldwide but varies in incidence among different ethnic groups. The disease has a strong genetic component but also responds to environmental factors such as infections. Psoriasis typically presents as chronic, symmetrical, erythematous, scaling papules and plaques, though it can manifest in various forms, including plaque psoriasis, guttate psoriasis, flexural psoriasis, erythroderma, generalized pustular psoriasis, palmoplantar pustulosis, and psoriatic nail disease. The epidemiology of psoriasis is characterized by a bimodal age of onset, with the first peak occurring around 15 to 20 years of age and the second peak at 55 to 60 years. Genetic studies have identified multiple susceptibility loci, with PSORS1 on chromosome 6p being the most significant. Environmental factors, such as infections, also play a crucial role in the development and progression of psoriasis. Clinically, psoriasis can affect various body sites, including the scalp, elbows, knees, lumbar sacral area, and body folds. It can be highly variable in morphology, distribution, and severity, ranging from small, tear-shaped papules to pustules and generalized erythema. Psoriasis can also involve the oral mucosa and tongue, leading to conditions like geographic tongue. The impact of psoriasis on quality of life is significant, affecting patients' social, psychological, and physical well-being. Psychological aspects, such as stigma, worry, and anxiety, are common among patients, contributing to disability and depression. Quality of life measures, such as the Psoriasis Area and Severity Index (PASI) and the Salford Psoriasis Index (SPI), are used to assess the effectiveness of treatments. However, the correlation between physical measures and quality of life is often poor, highlighting the need for more comprehensive assessments that consider both physical and psychological aspects of the disease.Psoriasis is a common, chronic, and recurrent immune-mediated skin disease that can significantly impact the physical, emotional, and psychosocial well-being of affected patients. It is prevalent worldwide but varies in incidence among different ethnic groups. The disease has a strong genetic component but also responds to environmental factors such as infections. Psoriasis typically presents as chronic, symmetrical, erythematous, scaling papules and plaques, though it can manifest in various forms, including plaque psoriasis, guttate psoriasis, flexural psoriasis, erythroderma, generalized pustular psoriasis, palmoplantar pustulosis, and psoriatic nail disease. The epidemiology of psoriasis is characterized by a bimodal age of onset, with the first peak occurring around 15 to 20 years of age and the second peak at 55 to 60 years. Genetic studies have identified multiple susceptibility loci, with PSORS1 on chromosome 6p being the most significant. Environmental factors, such as infections, also play a crucial role in the development and progression of psoriasis. Clinically, psoriasis can affect various body sites, including the scalp, elbows, knees, lumbar sacral area, and body folds. It can be highly variable in morphology, distribution, and severity, ranging from small, tear-shaped papules to pustules and generalized erythema. Psoriasis can also involve the oral mucosa and tongue, leading to conditions like geographic tongue. The impact of psoriasis on quality of life is significant, affecting patients' social, psychological, and physical well-being. Psychological aspects, such as stigma, worry, and anxiety, are common among patients, contributing to disability and depression. Quality of life measures, such as the Psoriasis Area and Severity Index (PASI) and the Salford Psoriasis Index (SPI), are used to assess the effectiveness of treatments. However, the correlation between physical measures and quality of life is often poor, highlighting the need for more comprehensive assessments that consider both physical and psychological aspects of the disease.