Psoriatic arthritis (PsA) is a unique inflammatory arthritis associated with psoriasis, affecting 0.3% to 1% of the population. Initially, PsA presents as oligoarticular and mild, but it can progress to polyarticular and severe in at least 20% of patients. The clinical features of PsA include distal joint involvement, asymmetrical distribution, and lower levels of tenderness compared to rheumatoid arthritis (RA). PsA is associated with human leucocyte antigen (HLA) class I alleles and has distinct patterns of presentation, such as distal predominant, oligoarticular asymmetrical, polyarticular RA-like, spondylitis, and arthritis mutilans. The disease is more aggressive than previously thought, with 55% of patients developing five or more deformed joints over 10 years. Patients with PsA have reduced quality of life and functional capacity, and they are at an increased risk of mortality, particularly from cardiovascular causes. Recent studies suggest that PsA may be more common than previously estimated, and its progression is influenced by factors such as HLA antigens and disease severity at presentation.Psoriatic arthritis (PsA) is a unique inflammatory arthritis associated with psoriasis, affecting 0.3% to 1% of the population. Initially, PsA presents as oligoarticular and mild, but it can progress to polyarticular and severe in at least 20% of patients. The clinical features of PsA include distal joint involvement, asymmetrical distribution, and lower levels of tenderness compared to rheumatoid arthritis (RA). PsA is associated with human leucocyte antigen (HLA) class I alleles and has distinct patterns of presentation, such as distal predominant, oligoarticular asymmetrical, polyarticular RA-like, spondylitis, and arthritis mutilans. The disease is more aggressive than previously thought, with 55% of patients developing five or more deformed joints over 10 years. Patients with PsA have reduced quality of life and functional capacity, and they are at an increased risk of mortality, particularly from cardiovascular causes. Recent studies suggest that PsA may be more common than previously estimated, and its progression is influenced by factors such as HLA antigens and disease severity at presentation.