PubChem, a widely used chemical information resource, has undergone significant improvements over the past two years. The platform now integrates data from over 100 new sources, including chemical-literature links from Thieme Chemistry, chemical and physical property links from SpringerMaterials, and patent links from the World Intellectual Properties Organization (WIPO). These additions have expanded PubChem's content, with over 293 million depositor-provided substance descriptions, 111 million unique chemical structures, and 271 million bioactivity data points. In response to the COVID-19 pandemic, PubChem created a special data collection containing relevant information about the virus and its associated chemicals. The platform also introduced several new services, such as the PubChem Periodic Table, Element pages, Pathway pages, and Knowledge panels, to enhance user experience and data exploration. Additionally, PubChem's web interfaces were redesigned to improve mobile accessibility and search capabilities, allowing users to search multiple data collections simultaneously and perform various types of structure searches. These updates collectively aim to better serve the scientific community and the general public by providing more comprehensive and accessible chemical information.PubChem, a widely used chemical information resource, has undergone significant improvements over the past two years. The platform now integrates data from over 100 new sources, including chemical-literature links from Thieme Chemistry, chemical and physical property links from SpringerMaterials, and patent links from the World Intellectual Properties Organization (WIPO). These additions have expanded PubChem's content, with over 293 million depositor-provided substance descriptions, 111 million unique chemical structures, and 271 million bioactivity data points. In response to the COVID-19 pandemic, PubChem created a special data collection containing relevant information about the virus and its associated chemicals. The platform also introduced several new services, such as the PubChem Periodic Table, Element pages, Pathway pages, and Knowledge panels, to enhance user experience and data exploration. Additionally, PubChem's web interfaces were redesigned to improve mobile accessibility and search capabilities, allowing users to search multiple data collections simultaneously and perform various types of structure searches. These updates collectively aim to better serve the scientific community and the general public by providing more comprehensive and accessible chemical information.