The article quantifies the threats to imperiled species in the United States, focusing on habitat destruction, alien species, pollution, overexploitation, and disease. It highlights that habitat destruction is the single greatest threat to biodiversity, followed by the spread of alien species. The study analyzed data from 2490 imperiled species, subspecies, and populations, finding that habitat loss affects 85% of the species, while alien species affect 49%. Pollution is a significant threat to aquatic species, and disease is a major threat to Hawaiian birds. The study also examined the causes of habitat destruction, identifying agriculture, commercial development, water development, and infrastructure development as leading threats. The findings suggest that alien species are a growing threat, particularly in Hawaii. The study also notes that the rate of alien species introductions has not consistently increased over time, but the cumulative number of alien species in the United States has risen significantly. Climate change is expected to become a major threat in the future. The study concludes that habitat loss and alien species are the most significant threats to biodiversity, and that conservation efforts must address these threats through active management. The study also highlights the need for incentives to encourage landowners to manage their property to benefit endangered species. The findings have important implications for the long-term protection of imperiled species in the United States.The article quantifies the threats to imperiled species in the United States, focusing on habitat destruction, alien species, pollution, overexploitation, and disease. It highlights that habitat destruction is the single greatest threat to biodiversity, followed by the spread of alien species. The study analyzed data from 2490 imperiled species, subspecies, and populations, finding that habitat loss affects 85% of the species, while alien species affect 49%. Pollution is a significant threat to aquatic species, and disease is a major threat to Hawaiian birds. The study also examined the causes of habitat destruction, identifying agriculture, commercial development, water development, and infrastructure development as leading threats. The findings suggest that alien species are a growing threat, particularly in Hawaii. The study also notes that the rate of alien species introductions has not consistently increased over time, but the cumulative number of alien species in the United States has risen significantly. Climate change is expected to become a major threat in the future. The study concludes that habitat loss and alien species are the most significant threats to biodiversity, and that conservation efforts must address these threats through active management. The study also highlights the need for incentives to encourage landowners to manage their property to benefit endangered species. The findings have important implications for the long-term protection of imperiled species in the United States.