This study quantifies the impact of human mobility on malaria transmission using mobile phone data and malaria prevalence information from Kenya. The research identifies key routes of parasite importation between regions, highlighting the role of human movement in spreading malaria. The analysis reveals that local "hotspots" of malaria prevalence, driven by complex interactions between the parasite and its hosts, are critical targets for intervention. Human travel can increase parasite dispersal beyond mosquito dispersal alone, necessitating consideration of human travel in malaria control strategies. The study maps parasite dispersal routes by human carriers, identifying both "source" and "sink" regions. It finds that Nairobi is a major hub for human movement, with significant parasite importation from the coast, Lake Victoria, and low endemicity regions. Visitors contribute to transmission in areas receptive to it, but have less impact in Nairobi where vector populations are scarce. The parasite movement network is dominated by importation around Lake Victoria, with relatively low importation rates between the lake and the coast. The high spatial resolution of the mobility data allows pinpointing settlements that receive or transmit a high volume of parasites. The study shows that returning residents play a key role in importing parasites to major parasite sinks, while visitors from high endemicity areas contribute significantly to importation. The analysis also highlights the importance of controlling imported infections in areas with low malaria prevalence to achieve elimination. The study's findings suggest that control programs should focus on reducing transmission in high-risk areas and targeting human traffic between regions. The results provide insights into the spatial dynamics of malaria transmission and the importance of human mobility in its spread. The study underscores the need for targeted interventions in areas with high parasite importation rates and highlights the role of human movement in malaria transmission. The findings have implications for future malaria elimination strategies, emphasizing the importance of understanding and managing human mobility in malaria control.This study quantifies the impact of human mobility on malaria transmission using mobile phone data and malaria prevalence information from Kenya. The research identifies key routes of parasite importation between regions, highlighting the role of human movement in spreading malaria. The analysis reveals that local "hotspots" of malaria prevalence, driven by complex interactions between the parasite and its hosts, are critical targets for intervention. Human travel can increase parasite dispersal beyond mosquito dispersal alone, necessitating consideration of human travel in malaria control strategies. The study maps parasite dispersal routes by human carriers, identifying both "source" and "sink" regions. It finds that Nairobi is a major hub for human movement, with significant parasite importation from the coast, Lake Victoria, and low endemicity regions. Visitors contribute to transmission in areas receptive to it, but have less impact in Nairobi where vector populations are scarce. The parasite movement network is dominated by importation around Lake Victoria, with relatively low importation rates between the lake and the coast. The high spatial resolution of the mobility data allows pinpointing settlements that receive or transmit a high volume of parasites. The study shows that returning residents play a key role in importing parasites to major parasite sinks, while visitors from high endemicity areas contribute significantly to importation. The analysis also highlights the importance of controlling imported infections in areas with low malaria prevalence to achieve elimination. The study's findings suggest that control programs should focus on reducing transmission in high-risk areas and targeting human traffic between regions. The results provide insights into the spatial dynamics of malaria transmission and the importance of human mobility in its spread. The study underscores the need for targeted interventions in areas with high parasite importation rates and highlights the role of human movement in malaria transmission. The findings have implications for future malaria elimination strategies, emphasizing the importance of understanding and managing human mobility in malaria control.