The article discusses the development of a method for quantitative analysis of urine vapor and breath using gas-liquid partition chromatography. The authors, including Linus Pauling, Arthur B. Robinson, Roy Teranishi, and Paul Cary, describe how a completely defined diet consisting of small molecules can be used to standardize body fluids, allowing for precise measurements of about 250 substances in breath and 280 substances in urine vapor. This technique is aimed at advancing orthomolecular medicine, which focuses on maintaining health and treating diseases by optimizing the concentrations of essential substances in the body. The method involves placing subjects on a standardized diet for several days to eliminate intestinal flora and achieve consistent results. The authors highlight the potential of this technique for personalized health management and differential diagnosis of diseases. The experimental methods detail the use of a Varian Aerograph model 2100 gas chromatograph with specific temperature programming and detection systems, along with the purification and flow regulation of gases.The article discusses the development of a method for quantitative analysis of urine vapor and breath using gas-liquid partition chromatography. The authors, including Linus Pauling, Arthur B. Robinson, Roy Teranishi, and Paul Cary, describe how a completely defined diet consisting of small molecules can be used to standardize body fluids, allowing for precise measurements of about 250 substances in breath and 280 substances in urine vapor. This technique is aimed at advancing orthomolecular medicine, which focuses on maintaining health and treating diseases by optimizing the concentrations of essential substances in the body. The method involves placing subjects on a standardized diet for several days to eliminate intestinal flora and achieve consistent results. The authors highlight the potential of this technique for personalized health management and differential diagnosis of diseases. The experimental methods detail the use of a Varian Aerograph model 2100 gas chromatograph with specific temperature programming and detection systems, along with the purification and flow regulation of gases.