Quantitative phase imaging with a compact meta-microscope

Quantitative phase imaging with a compact meta-microscope

(2024)1:4 | Junyi Wang, Rongtao Yu, Xin Ye, Jiacheng Sun, Jian Li, Chunyu Huang, Xingjian Xiao, Jitao Ji, Wenjing Shen, Zuoxiu Tie, Chen Chen, Shining Zhu, Tao Li
This article presents a novel approach to quantitative phase imaging (QPI) using a dispersive metalens, which enables non-mechanical optical zooming and compact integration with a commercial CMOS image sensor. The dispersive nature of the metalens allows for spectral focal tuning, enabling the capture of multiple through-focus intensity images by changing the illumination wavelength. This method is validated through the retrieval of surface phase profiles from a microlens array and a phase resolution target, demonstrating high phase detection accuracy (deviation less than 0.03 wavelength). The proposed system, known as a meta-microscope, is compact (36 × 36 × 14 mm³) and shows good performance in imaging unstained bio-samples. The meta-microscope's ability to integrate with a CMOS image sensor and its small size make it suitable for applications requiring portability, such as point-of-care testing. The article also discusses the design and characterization of the metalens, including its polarization conversion ratio and imaging performance, and provides detailed experimental setups and results.This article presents a novel approach to quantitative phase imaging (QPI) using a dispersive metalens, which enables non-mechanical optical zooming and compact integration with a commercial CMOS image sensor. The dispersive nature of the metalens allows for spectral focal tuning, enabling the capture of multiple through-focus intensity images by changing the illumination wavelength. This method is validated through the retrieval of surface phase profiles from a microlens array and a phase resolution target, demonstrating high phase detection accuracy (deviation less than 0.03 wavelength). The proposed system, known as a meta-microscope, is compact (36 × 36 × 14 mm³) and shows good performance in imaging unstained bio-samples. The meta-microscope's ability to integrate with a CMOS image sensor and its small size make it suitable for applications requiring portability, such as point-of-care testing. The article also discusses the design and characterization of the metalens, including its polarization conversion ratio and imaging performance, and provides detailed experimental setups and results.
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