The article discusses the role of reactive oxygen species (ROS) and redox homeostasis in cancer cell metabolism and growth. It highlights how tumor cells produce high levels of ROS due to genetic alterations, which leads to oxidative stress and genomic instability. The review emphasizes the importance of mitochondria in regulating the interplay between redox homeostasis and metabolism in tumor cells. It also explores the potential therapeutic strategies that target metabolic pathways or ROS-scavenging mechanisms to enhance the efficacy of chemotherapy and radiotherapy. The authors suggest that disrupting the redox balance in cancer cells could be a promising approach to improve treatment outcomes.The article discusses the role of reactive oxygen species (ROS) and redox homeostasis in cancer cell metabolism and growth. It highlights how tumor cells produce high levels of ROS due to genetic alterations, which leads to oxidative stress and genomic instability. The review emphasizes the importance of mitochondria in regulating the interplay between redox homeostasis and metabolism in tumor cells. It also explores the potential therapeutic strategies that target metabolic pathways or ROS-scavenging mechanisms to enhance the efficacy of chemotherapy and radiotherapy. The authors suggest that disrupting the redox balance in cancer cells could be a promising approach to improve treatment outcomes.