Radius of Gyration as an Indicator of Protein Structure Compactness

Radius of Gyration as an Indicator of Protein Structure Compactness

2008 | M. Yu. Lobanov, N. S. Bogatyreva, and O. V. Galzitskaya
The article "Radius of Gyration as an Indicator of Protein Structure Compactness" by M. Yu. Lobanov, N. S. Bogatyreva, and O. V. Galzitskaya explores the relationship between protein structure compactness and the radius of gyration. The study analyzed 3769 protein domains from four major classes (α, β, α/β, and α + β) to identify characteristic radii of gyration that reflect the compactness of protein structures. α-proteins have the highest radius of gyration, indicating less tight packing compared to β- and (α + β)-proteins. α/β-proteins exhibit the lowest radius of gyration, suggesting the tightest packing. The normalized radius of gyration, which is independent of protein size, further confirms that α/β-proteins are the most compact, while α-proteins are the loosest. Additionally, proteins with a three-state folding mechanism are more compact than those with a two-state mechanism. The study highlights the importance of protein structure compactness in understanding folding rates and stability.The article "Radius of Gyration as an Indicator of Protein Structure Compactness" by M. Yu. Lobanov, N. S. Bogatyreva, and O. V. Galzitskaya explores the relationship between protein structure compactness and the radius of gyration. The study analyzed 3769 protein domains from four major classes (α, β, α/β, and α + β) to identify characteristic radii of gyration that reflect the compactness of protein structures. α-proteins have the highest radius of gyration, indicating less tight packing compared to β- and (α + β)-proteins. α/β-proteins exhibit the lowest radius of gyration, suggesting the tightest packing. The normalized radius of gyration, which is independent of protein size, further confirms that α/β-proteins are the most compact, while α-proteins are the loosest. Additionally, proteins with a three-state folding mechanism are more compact than those with a two-state mechanism. The study highlights the importance of protein structure compactness in understanding folding rates and stability.
Reach us at info@study.space
[slides and audio] Radius of gyration as an indicator of protein structure compactness