This randomized controlled trial investigated the effect of compression stockings on the development of post-thrombotic syndrome in patients with symptomatic proximal deep-vein thrombosis. The study included 194 patients who were randomly assigned to wear either compression stockings or no stockings for at least 2 years. Post-thrombotic syndrome was assessed using a standardized scoring system that combined clinical characteristics and objective leg measurements. The primary outcome measure was the cumulative incidence of mild-to-moderate post-thrombotic syndrome. The results showed that mild-to-moderate post-thrombotic syndrome occurred in 20% of patients in the stocking group and 47% in the control group (p<0.001). Severe post-thrombotic syndrome developed in 11% of patients in the stocking group and 23% in the control group (p<0.001). The study concluded that about 60% of patients with a first episode of proximal deep-vein thrombosis develop post-thrombotic syndrome within 2 years, and the use of compression stockings reduced this rate by approximately 50%.This randomized controlled trial investigated the effect of compression stockings on the development of post-thrombotic syndrome in patients with symptomatic proximal deep-vein thrombosis. The study included 194 patients who were randomly assigned to wear either compression stockings or no stockings for at least 2 years. Post-thrombotic syndrome was assessed using a standardized scoring system that combined clinical characteristics and objective leg measurements. The primary outcome measure was the cumulative incidence of mild-to-moderate post-thrombotic syndrome. The results showed that mild-to-moderate post-thrombotic syndrome occurred in 20% of patients in the stocking group and 47% in the control group (p<0.001). Severe post-thrombotic syndrome developed in 11% of patients in the stocking group and 23% in the control group (p<0.001). The study concluded that about 60% of patients with a first episode of proximal deep-vein thrombosis develop post-thrombotic syndrome within 2 years, and the use of compression stockings reduced this rate by approximately 50%.