The LEAP (Learning Early About Peanut) study aimed to determine the effectiveness of early peanut consumption versus avoidance in preventing peanut allergy in high-risk infants. The study randomly assigned 640 infants with severe eczema, egg allergy, or both to consume or avoid peanuts until 60 months of age. The primary outcome was the proportion of participants with peanut allergy at 60 months of age, assessed independently in each cohort. Among infants with negative skin-prick test results, the prevalence of peanut allergy was 13.7% in the avoidance group and 1.9% in the consumption group (P<0.001). Among infants with positive skin-prick test results, the prevalence was 35.3% in the avoidance group and 10.6% in the consumption group (P = 0.004). The consumption group showed a significant increase in peanut-specific IgG4 antibody levels, while the avoidance group had higher levels of peanut-specific IgE antibody. The study concluded that early and sustained peanut consumption significantly reduced the development of peanut allergy in high-risk infants, suggesting that early exposure may offer protection against peanut allergy.The LEAP (Learning Early About Peanut) study aimed to determine the effectiveness of early peanut consumption versus avoidance in preventing peanut allergy in high-risk infants. The study randomly assigned 640 infants with severe eczema, egg allergy, or both to consume or avoid peanuts until 60 months of age. The primary outcome was the proportion of participants with peanut allergy at 60 months of age, assessed independently in each cohort. Among infants with negative skin-prick test results, the prevalence of peanut allergy was 13.7% in the avoidance group and 1.9% in the consumption group (P<0.001). Among infants with positive skin-prick test results, the prevalence was 35.3% in the avoidance group and 10.6% in the consumption group (P = 0.004). The consumption group showed a significant increase in peanut-specific IgG4 antibody levels, while the avoidance group had higher levels of peanut-specific IgE antibody. The study concluded that early and sustained peanut consumption significantly reduced the development of peanut allergy in high-risk infants, suggesting that early exposure may offer protection against peanut allergy.