The New England Journal of Medicine published a study on the rate of pregnancy-related relapse in multiple sclerosis (MS). The study, conducted across 12 European countries, followed 254 women with MS during 269 pregnancies. The women were monitored during their pregnancies and for up to 12 months post-delivery to assess relapse rates and disability scores. The results showed that the relapse rate per woman per year decreased during pregnancy, especially in the third trimester, and increased in the first three months postpartum before returning to the prepregnancy rate. The mean relapse rate before pregnancy was 0.7±0.9 per woman per year, while during the first trimester it was 0.5±1.3, during the second trimester 0.6±1.6, and during the third trimester 0.2±1.0. After delivery, the relapse rate increased to 1.2±2.0 in the first three months postpartum. The Kurtzke Expanded Disability Status Scale (EDSS) scores, which measure disability, worsened by 0.7 points over 33 months of follow-up, with no apparent acceleration during the postpartum period. Neither breast-feeding nor epidural analgesia had an adverse effect on relapse rates or disability progression. The study concluded that pregnancy leads to a decrease in relapse rates, particularly in the third trimester, and an increase in the first three months postpartum, followed by a return to the prepregnancy rate. The findings suggest that pregnancy may have a protective effect on MS, but the postpartum period may be a time of increased relapse risk. The study was a large, prospective, observational study designed to determine the effect of pregnancy and the postpartum state on the course of MS, along with the effects of breast-feeding and epidural analgesia. The study found that the overall rate of progression of disability did not change during the study period, despite the increase in relapse rate in the first three months postpartum. The results are consistent with previous studies suggesting that pregnancy may lead to a decrease in relapse rates, while the postpartum period may be a time of increased relapse risk. The study also found that epidural analgesia and breast-feeding did not increase the risk of relapse or worsening disability in the postpartum period. The findings support the idea that pregnancy may have a protective effect on MS, but the postpartum period may be a time of increased relapse risk. The study is an important contribution to the understanding of the relationship between pregnancy and MS, and may have implications for the management of MS in pregnant women.The New England Journal of Medicine published a study on the rate of pregnancy-related relapse in multiple sclerosis (MS). The study, conducted across 12 European countries, followed 254 women with MS during 269 pregnancies. The women were monitored during their pregnancies and for up to 12 months post-delivery to assess relapse rates and disability scores. The results showed that the relapse rate per woman per year decreased during pregnancy, especially in the third trimester, and increased in the first three months postpartum before returning to the prepregnancy rate. The mean relapse rate before pregnancy was 0.7±0.9 per woman per year, while during the first trimester it was 0.5±1.3, during the second trimester 0.6±1.6, and during the third trimester 0.2±1.0. After delivery, the relapse rate increased to 1.2±2.0 in the first three months postpartum. The Kurtzke Expanded Disability Status Scale (EDSS) scores, which measure disability, worsened by 0.7 points over 33 months of follow-up, with no apparent acceleration during the postpartum period. Neither breast-feeding nor epidural analgesia had an adverse effect on relapse rates or disability progression. The study concluded that pregnancy leads to a decrease in relapse rates, particularly in the third trimester, and an increase in the first three months postpartum, followed by a return to the prepregnancy rate. The findings suggest that pregnancy may have a protective effect on MS, but the postpartum period may be a time of increased relapse risk. The study was a large, prospective, observational study designed to determine the effect of pregnancy and the postpartum state on the course of MS, along with the effects of breast-feeding and epidural analgesia. The study found that the overall rate of progression of disability did not change during the study period, despite the increase in relapse rate in the first three months postpartum. The results are consistent with previous studies suggesting that pregnancy may lead to a decrease in relapse rates, while the postpartum period may be a time of increased relapse risk. The study also found that epidural analgesia and breast-feeding did not increase the risk of relapse or worsening disability in the postpartum period. The findings support the idea that pregnancy may have a protective effect on MS, but the postpartum period may be a time of increased relapse risk. The study is an important contribution to the understanding of the relationship between pregnancy and MS, and may have implications for the management of MS in pregnant women.