The article discusses the need to reduce the burden of mental illness through innovative approaches in psychological interventions. Despite significant progress in psychological treatments, mental health professionals are not likely to reduce the prevalence, incidence, and burden of mental illness without a major shift in intervention research and clinical practice. A portfolio of delivery models is needed to address the issue. The article highlights various models of delivery, including technology, special settings, nontraditional service providers, self-help interventions, and the media. It emphasizes the importance of integrating prevention and treatment, developing assessment and a national database for monitoring mental illness, and addressing contextual issues that influence treatment delivery. The article also discusses the need for multidisciplinary collaborations to reduce the burden of mental illness. The focus is on the need for diverse delivery models to reach a broader population, including those in underserved areas and populations. The article also highlights the potential of technology, such as the Internet, telephone, and smartphones, to deliver interventions more widely. It also discusses the use of special settings, such as physician's offices, and the potential of nonprofessionals to provide interventions. The article concludes that a portfolio of delivery models is essential to reduce the burden of mental illness.The article discusses the need to reduce the burden of mental illness through innovative approaches in psychological interventions. Despite significant progress in psychological treatments, mental health professionals are not likely to reduce the prevalence, incidence, and burden of mental illness without a major shift in intervention research and clinical practice. A portfolio of delivery models is needed to address the issue. The article highlights various models of delivery, including technology, special settings, nontraditional service providers, self-help interventions, and the media. It emphasizes the importance of integrating prevention and treatment, developing assessment and a national database for monitoring mental illness, and addressing contextual issues that influence treatment delivery. The article also discusses the need for multidisciplinary collaborations to reduce the burden of mental illness. The focus is on the need for diverse delivery models to reach a broader population, including those in underserved areas and populations. The article also highlights the potential of technology, such as the Internet, telephone, and smartphones, to deliver interventions more widely. It also discusses the use of special settings, such as physician's offices, and the potential of nonprofessionals to provide interventions. The article concludes that a portfolio of delivery models is essential to reduce the burden of mental illness.