Recent Advances in Scaffolds for Guided Bone Regeneration The review discusses the challenges in repairing moderate to severe alveolar bone defects and the limitations of current bone grafting techniques, such as high morbidity, suboptimal resorption rates, and poor structural integrity. It highlights the potential of biomimetic scaffolds with tailored characteristics to modulate cell and tissue interactions, enhancing bone regeneration. The article covers scaffold design, fabrication methods, and their role in guided bone regeneration (GBR) and dental implant placement. It emphasizes the importance of scaffolds in tissue engineering and regenerative medicine, including their ability to deliver therapeutic agents, promote tissue healing, and support bone repair. Key properties of scaffolds include biocompatibility, bioactivity, physicochemical similarity to the extracellular matrix, resistance to oral microenvironment conditions, sufficient porosity, and controlled degradation. The review discusses various scaffold fabrication techniques, such as electrospinning, additive manufacturing, bioprinting, freeze drying, solvent casting, gas foaming, and decellularization. These methods produce scaffolds with different architectures and properties, crucial for bone regeneration. The article also explores the use of different biomaterials, including autografts, allografts, xenografts, and synthetic alloplasts, and their respective advantages and limitations. It highlights the development of multiphasic scaffolds with distinct compartments to mimic the complex structure of bone and promote regeneration. Additionally, it discusses the role of membranes in GBR, their ability to prevent unwanted cell ingrowth, and their contribution to bone regeneration. The review concludes that the advancement of scaffold technology, including personalized scaffolds fabricated using CAD/CAM techniques, holds promise for improving the outcomes of bone regeneration and dental implant placement. The integration of scaffolds with growth factors, cells, and bioactive molecules is essential for effective tissue engineering and regenerative medicine. The development of smart scaffolds with responsive properties and personalized scaffolds tailored to individual anatomical needs represents the future direction of bone regeneration research.Recent Advances in Scaffolds for Guided Bone Regeneration The review discusses the challenges in repairing moderate to severe alveolar bone defects and the limitations of current bone grafting techniques, such as high morbidity, suboptimal resorption rates, and poor structural integrity. It highlights the potential of biomimetic scaffolds with tailored characteristics to modulate cell and tissue interactions, enhancing bone regeneration. The article covers scaffold design, fabrication methods, and their role in guided bone regeneration (GBR) and dental implant placement. It emphasizes the importance of scaffolds in tissue engineering and regenerative medicine, including their ability to deliver therapeutic agents, promote tissue healing, and support bone repair. Key properties of scaffolds include biocompatibility, bioactivity, physicochemical similarity to the extracellular matrix, resistance to oral microenvironment conditions, sufficient porosity, and controlled degradation. The review discusses various scaffold fabrication techniques, such as electrospinning, additive manufacturing, bioprinting, freeze drying, solvent casting, gas foaming, and decellularization. These methods produce scaffolds with different architectures and properties, crucial for bone regeneration. The article also explores the use of different biomaterials, including autografts, allografts, xenografts, and synthetic alloplasts, and their respective advantages and limitations. It highlights the development of multiphasic scaffolds with distinct compartments to mimic the complex structure of bone and promote regeneration. Additionally, it discusses the role of membranes in GBR, their ability to prevent unwanted cell ingrowth, and their contribution to bone regeneration. The review concludes that the advancement of scaffold technology, including personalized scaffolds fabricated using CAD/CAM techniques, holds promise for improving the outcomes of bone regeneration and dental implant placement. The integration of scaffolds with growth factors, cells, and bioactive molecules is essential for effective tissue engineering and regenerative medicine. The development of smart scaffolds with responsive properties and personalized scaffolds tailored to individual anatomical needs represents the future direction of bone regeneration research.