Psoriasis (PSO) is a chronic autoimmune skin condition characterized by rapid and excessive skin cell growth, leading to thick, red, and scaly patches. Conventional topical treatments, such as corticosteroids, vitamin D analogs, and retinoids, are often used but have limitations, including poor penetration and side effects. Nanoparticles (NPs) offer a promising alternative by enhancing drug penetration, stability, and controlled release, making them attractive for targeted delivery to affected skin areas. This review discusses recent advancements in using NPs for topical therapy of PSO, highlighting their unique properties and the results of in vitro, ex vivo, and in vivo studies. Key types of NPs, including liposomes, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), and nanosponges, are explored, along with their potential benefits and challenges. The review also covers the pathophysiology of PSO, the challenges in topical drug delivery, and the advantages of nanotechnology in medicine. Recent clinical trials and formulations of NP-based therapies for PSO are presented, emphasizing the need for further research to optimize safety and efficacy.Psoriasis (PSO) is a chronic autoimmune skin condition characterized by rapid and excessive skin cell growth, leading to thick, red, and scaly patches. Conventional topical treatments, such as corticosteroids, vitamin D analogs, and retinoids, are often used but have limitations, including poor penetration and side effects. Nanoparticles (NPs) offer a promising alternative by enhancing drug penetration, stability, and controlled release, making them attractive for targeted delivery to affected skin areas. This review discusses recent advancements in using NPs for topical therapy of PSO, highlighting their unique properties and the results of in vitro, ex vivo, and in vivo studies. Key types of NPs, including liposomes, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), and nanosponges, are explored, along with their potential benefits and challenges. The review also covers the pathophysiology of PSO, the challenges in topical drug delivery, and the advantages of nanotechnology in medicine. Recent clinical trials and formulations of NP-based therapies for PSO are presented, emphasizing the need for further research to optimize safety and efficacy.