14 February 2024 | Olga Kammona, Evgenia Tsanaktsidou, Costas Kiparissides
The paper reviews recent advancements in 3D-(bio)printed hydrogels for wound healing applications, focusing on their in vitro and in vivo performance. Hydrogels are favored for their ability to mimic the extracellular matrix (ECM), provide a moist environment, and encapsulate bioactive agents. The review covers various types of hydrogels, including bioactive/antibacterial, composite, and cell-laden hydrogels, and discusses the materials, crosslinking methods, printing techniques, and bioactive agents used. Key advancements include the use of advanced polymers, such as sodium alginate, gelatin, and chitosan, and the integration of nanoparticles and cells. The paper also highlights the potential of 3D bioprinting to create multifunctional hydrogels with controlled microstructures and bioactive agent release, enhancing wound healing and reducing healing time.The paper reviews recent advancements in 3D-(bio)printed hydrogels for wound healing applications, focusing on their in vitro and in vivo performance. Hydrogels are favored for their ability to mimic the extracellular matrix (ECM), provide a moist environment, and encapsulate bioactive agents. The review covers various types of hydrogels, including bioactive/antibacterial, composite, and cell-laden hydrogels, and discusses the materials, crosslinking methods, printing techniques, and bioactive agents used. Key advancements include the use of advanced polymers, such as sodium alginate, gelatin, and chitosan, and the integration of nanoparticles and cells. The paper also highlights the potential of 3D bioprinting to create multifunctional hydrogels with controlled microstructures and bioactive agent release, enhancing wound healing and reducing healing time.