Recent developments in single-entity electrochemistry (SEE) highlight advancements in nanoelectrodes, single-cell electroanalysis, stochastic particle collision experiments, and opto-electrochemistry. Nanoelectrodes enable precise measurements of single entities like nanoparticles, proteins, and cells, with applications in electrocatalysis, single-cell analysis, and structural studies. Techniques such as the "pick-and-drop" method allow for controlled placement of nanoparticles on electrodes, enabling detailed studies of tandem catalysis and structural changes. Single-cell electroanalysis involves nanoelectrodes for monitoring cellular processes, including intracellular electrochemical measurements and the use of nanopipettes for high-resolution analysis. Stochastic particle collision experiments focus on amperometric methods to study single-particle interactions, with recent advances addressing electrophoretic edge effects in ultramicroelectrodes. Opto-electrochemistry combines optical microscopy with electrochemical techniques to monitor structural and compositional changes in single entities, such as plasmonic nanoparticles. Nanopore and ion channel measurements have also advanced, with developments in biological nanopores and stable ion channel current measurements. Electrochemical scanning probe microscopy (SECCM) enables localized electrochemical studies of single nanocrystals, revealing structure-activity relationships. These advancements underscore the growing importance of SEE in understanding electrochemical processes at the single-entity level, with applications in catalysis, biology, and materials science.Recent developments in single-entity electrochemistry (SEE) highlight advancements in nanoelectrodes, single-cell electroanalysis, stochastic particle collision experiments, and opto-electrochemistry. Nanoelectrodes enable precise measurements of single entities like nanoparticles, proteins, and cells, with applications in electrocatalysis, single-cell analysis, and structural studies. Techniques such as the "pick-and-drop" method allow for controlled placement of nanoparticles on electrodes, enabling detailed studies of tandem catalysis and structural changes. Single-cell electroanalysis involves nanoelectrodes for monitoring cellular processes, including intracellular electrochemical measurements and the use of nanopipettes for high-resolution analysis. Stochastic particle collision experiments focus on amperometric methods to study single-particle interactions, with recent advances addressing electrophoretic edge effects in ultramicroelectrodes. Opto-electrochemistry combines optical microscopy with electrochemical techniques to monitor structural and compositional changes in single entities, such as plasmonic nanoparticles. Nanopore and ion channel measurements have also advanced, with developments in biological nanopores and stable ion channel current measurements. Electrochemical scanning probe microscopy (SECCM) enables localized electrochemical studies of single nanocrystals, revealing structure-activity relationships. These advancements underscore the growing importance of SEE in understanding electrochemical processes at the single-entity level, with applications in catalysis, biology, and materials science.