Recent insights into glucose-responsive Concanavalin A-based smart hydrogels for controlled insulin delivery are presented. Concanavalin A (Con A), a natural protein from sword bean plants, has high affinity for glucose and mannose, making it suitable for glucose-responsive materials. Con A-based hydrogels can detect glucose levels and release insulin in response to glucose concentration changes, offering potential for diabetes management. These hydrogels are designed to respond to environmental glucose levels, enabling self-regulated insulin delivery. Con A can be incorporated into hydrogel-based materials to create minimally invasive glucose sensors and insulin delivery systems. The development of glucose-sensitive hydrogels involves the reversible binding of glucose to Con A, which displaces insulin and controls its release based on glucose concentration. Con A-based materials have been used to create biosensors, drug delivery devices, and smart hydrogels for glucose monitoring and insulin release. The review highlights the potential of Con A-based hydrogels in diabetes theranostics, emphasizing their ability to maintain blood glucose levels within normal limits. The study also discusses the use of Con A in glucose-responsive systems, including hydrogels, microgels, nanoparticles, and films, for biosensing and drug delivery. Con A-based hydrogels have shown promise in controlling insulin release and improving glucose monitoring, with applications in diabetes management and cancer theranostics. The review underscores the importance of Con A in developing smart materials for glucose-responsive insulin delivery and highlights the potential of Con A-based hydrogels in improving diabetes therapy.Recent insights into glucose-responsive Concanavalin A-based smart hydrogels for controlled insulin delivery are presented. Concanavalin A (Con A), a natural protein from sword bean plants, has high affinity for glucose and mannose, making it suitable for glucose-responsive materials. Con A-based hydrogels can detect glucose levels and release insulin in response to glucose concentration changes, offering potential for diabetes management. These hydrogels are designed to respond to environmental glucose levels, enabling self-regulated insulin delivery. Con A can be incorporated into hydrogel-based materials to create minimally invasive glucose sensors and insulin delivery systems. The development of glucose-sensitive hydrogels involves the reversible binding of glucose to Con A, which displaces insulin and controls its release based on glucose concentration. Con A-based materials have been used to create biosensors, drug delivery devices, and smart hydrogels for glucose monitoring and insulin release. The review highlights the potential of Con A-based hydrogels in diabetes theranostics, emphasizing their ability to maintain blood glucose levels within normal limits. The study also discusses the use of Con A in glucose-responsive systems, including hydrogels, microgels, nanoparticles, and films, for biosensing and drug delivery. Con A-based hydrogels have shown promise in controlling insulin release and improving glucose monitoring, with applications in diabetes management and cancer theranostics. The review underscores the importance of Con A in developing smart materials for glucose-responsive insulin delivery and highlights the potential of Con A-based hydrogels in improving diabetes therapy.