This review discusses recent advances in bone tissue engineering scaffolds, focusing on their design, fabrication techniques, and performance in vitro and in vivo. Bone scaffolds are typically made of porous, biodegradable materials that support the growth of bone cells and promote bone formation and vascularization. Key requirements for an ideal scaffold include biocompatibility, mechanical properties matching those of host bone, interconnected porosity for nutrient and oxygen diffusion, and controlled degradation kinetics. Various fabrication techniques, such as solid freeform fabrication (SFF) and laser engineered net shaping (LENS™), are used to create these scaffolds. The review highlights the importance of biomolecule delivery, including growth factors and drugs, in enhancing osteogenesis and angiogenesis. Recent studies have shown that incorporating growth factors like BMP-2 and VEGF into scaffolds can significantly improve bone formation and vascularization. However, challenges remain, including the need for better control over scaffold degradation rates and the development of new material combinations that balance strength and biodegradability. The future of bone tissue engineering scaffolds lies in mimicking natural bone regeneration processes and optimizing the delivery of biomolecules to achieve optimal tissue integration and function.This review discusses recent advances in bone tissue engineering scaffolds, focusing on their design, fabrication techniques, and performance in vitro and in vivo. Bone scaffolds are typically made of porous, biodegradable materials that support the growth of bone cells and promote bone formation and vascularization. Key requirements for an ideal scaffold include biocompatibility, mechanical properties matching those of host bone, interconnected porosity for nutrient and oxygen diffusion, and controlled degradation kinetics. Various fabrication techniques, such as solid freeform fabrication (SFF) and laser engineered net shaping (LENS™), are used to create these scaffolds. The review highlights the importance of biomolecule delivery, including growth factors and drugs, in enhancing osteogenesis and angiogenesis. Recent studies have shown that incorporating growth factors like BMP-2 and VEGF into scaffolds can significantly improve bone formation and vascularization. However, challenges remain, including the need for better control over scaffold degradation rates and the development of new material combinations that balance strength and biodegradability. The future of bone tissue engineering scaffolds lies in mimicking natural bone regeneration processes and optimizing the delivery of biomolecules to achieve optimal tissue integration and function.