Recent advances in the fabrication of dECM-based composite materials for skin tissue engineering are reviewed. Chronic wounds are a significant medical and social issue, and dECM-based materials, which possess excellent biological properties, are used in clinical settings for skin regeneration. However, their application is limited by the complex external environment and the prolonged healing process. dECM-based composite materials, which combine dECM with other materials, have shown promise in promoting wound healing through antimicrobial activity and suitable degradability. Various fabrication techniques, including molding, electrospinning, and 3D printing, have been developed to create dECM-based composite materials with different forms, such as hydrogels, electrospun fibers, and bio-printed scaffolds. These materials have shown potential in wound healing by promoting cell growth, re-epithelization, angiogenesis, and inhibiting inflammation. Challenges remain in the clinical application of these materials, including the need for precise delivery of bioactive agents and the complexity of the wound microenvironment. The review highlights recent developments in dECM-based composite materials, emphasizing their potential in skin regeneration and the need for further research to improve their clinical translation.Recent advances in the fabrication of dECM-based composite materials for skin tissue engineering are reviewed. Chronic wounds are a significant medical and social issue, and dECM-based materials, which possess excellent biological properties, are used in clinical settings for skin regeneration. However, their application is limited by the complex external environment and the prolonged healing process. dECM-based composite materials, which combine dECM with other materials, have shown promise in promoting wound healing through antimicrobial activity and suitable degradability. Various fabrication techniques, including molding, electrospinning, and 3D printing, have been developed to create dECM-based composite materials with different forms, such as hydrogels, electrospun fibers, and bio-printed scaffolds. These materials have shown potential in wound healing by promoting cell growth, re-epithelization, angiogenesis, and inhibiting inflammation. Challenges remain in the clinical application of these materials, including the need for precise delivery of bioactive agents and the complexity of the wound microenvironment. The review highlights recent developments in dECM-based composite materials, emphasizing their potential in skin regeneration and the need for further research to improve their clinical translation.