Nickel catalysis has seen significant advancements in the past decade, offering a versatile platform for a wide range of chemical transformations. Unlike palladium, nickel's unique properties, such as facile oxidative addition and access to multiple oxidation states, enable it to perform challenging reactions. This review highlights recent developments in homogeneous nickel catalysis, focusing on synthetic outcomes and mechanisms. Nickel's ability to activate various bonds, including C–O and C–N, has expanded its utility in cross-coupling reactions, particularly with phenol derivatives, aryl halides, and aziridines. The development of efficient catalysts and ligands has improved the efficiency and selectivity of these reactions. Additionally, nickel has been used in reductive cross-coupling, allowing the formation of C–C bonds without the need for organometallic species. The field of nickel catalysis continues to evolve, with ongoing research aimed at improving the scope and efficiency of reactions, as well as developing new methods for challenging bond formations. Nickel's cost-effectiveness and air-stability make it an attractive alternative to palladium in many applications. Overall, nickel catalysis is a promising area of research with significant potential for future developments in organic synthesis.Nickel catalysis has seen significant advancements in the past decade, offering a versatile platform for a wide range of chemical transformations. Unlike palladium, nickel's unique properties, such as facile oxidative addition and access to multiple oxidation states, enable it to perform challenging reactions. This review highlights recent developments in homogeneous nickel catalysis, focusing on synthetic outcomes and mechanisms. Nickel's ability to activate various bonds, including C–O and C–N, has expanded its utility in cross-coupling reactions, particularly with phenol derivatives, aryl halides, and aziridines. The development of efficient catalysts and ligands has improved the efficiency and selectivity of these reactions. Additionally, nickel has been used in reductive cross-coupling, allowing the formation of C–C bonds without the need for organometallic species. The field of nickel catalysis continues to evolve, with ongoing research aimed at improving the scope and efficiency of reactions, as well as developing new methods for challenging bond formations. Nickel's cost-effectiveness and air-stability make it an attractive alternative to palladium in many applications. Overall, nickel catalysis is a promising area of research with significant potential for future developments in organic synthesis.