This review summarizes recent advances in multimodal sensing integration and decoupling strategies for tactile perception. Human skin perceives external stimuli through the synergistic action of tactile corpuscles. Soft electronics that mimic human skin's functions are significant for health monitoring and artificial sensation. Over the past decade, there has been significant development and convergence between multimodal tactile sensing devices and soft bioelectronics. However, traditional flexible electronics integrate monomodal sensing devices to achieve multimodal tactile sensing, resulting in high energy consumption, limited integration, and complex manufacturing processes. Various multimodal sensors and crosstalk-free sensing mechanisms have been proposed to bridge the gap between natural and artificial sensory systems. The review provides a comprehensive summary of tactile sensing mechanisms, integration design principles, signal-decoupling strategies, and current applications for multimodal tactile perception. It highlights current challenges and future perspectives to promote the development of multimodal tactile perception. Key topics include pressure, strain, temperature, and humidity sensing mechanisms, as well as multifunctional materials and signal-decoupling strategies. The review discusses the integration of monomodal sensors, multifunctional materials, multiple mechanism integration, and signal-decoupling strategies. It also exemplifies the applications of multiple tactile sensors in health-monitoring and artificial intelligence. Finally, it highlights challenges and prospects for multimodal tactile perception. The review discusses various sensing mechanisms for pressure, strain, temperature, and humidity, including piezoresistive, piezocapacitive, piezoelectric, triboelectric, and optical mechanisms. It also covers the development of multifunctional materials and the integration of multiple mechanisms for multimodal sensing. The review emphasizes the importance of signal decoupling strategies to achieve accurate and reliable multimodal tactile perception. The review concludes with a discussion on the challenges and future directions in the development of multimodal tactile sensing systems.This review summarizes recent advances in multimodal sensing integration and decoupling strategies for tactile perception. Human skin perceives external stimuli through the synergistic action of tactile corpuscles. Soft electronics that mimic human skin's functions are significant for health monitoring and artificial sensation. Over the past decade, there has been significant development and convergence between multimodal tactile sensing devices and soft bioelectronics. However, traditional flexible electronics integrate monomodal sensing devices to achieve multimodal tactile sensing, resulting in high energy consumption, limited integration, and complex manufacturing processes. Various multimodal sensors and crosstalk-free sensing mechanisms have been proposed to bridge the gap between natural and artificial sensory systems. The review provides a comprehensive summary of tactile sensing mechanisms, integration design principles, signal-decoupling strategies, and current applications for multimodal tactile perception. It highlights current challenges and future perspectives to promote the development of multimodal tactile perception. Key topics include pressure, strain, temperature, and humidity sensing mechanisms, as well as multifunctional materials and signal-decoupling strategies. The review discusses the integration of monomodal sensors, multifunctional materials, multiple mechanism integration, and signal-decoupling strategies. It also exemplifies the applications of multiple tactile sensors in health-monitoring and artificial intelligence. Finally, it highlights challenges and prospects for multimodal tactile perception. The review discusses various sensing mechanisms for pressure, strain, temperature, and humidity, including piezoresistive, piezocapacitive, piezoelectric, triboelectric, and optical mechanisms. It also covers the development of multifunctional materials and the integration of multiple mechanisms for multimodal sensing. The review emphasizes the importance of signal decoupling strategies to achieve accurate and reliable multimodal tactile perception. The review concludes with a discussion on the challenges and future directions in the development of multimodal tactile sensing systems.