This review discusses recent advances in understanding the antibacterial properties of flavonoids, a family of plant-derived compounds. Flavonoids exhibit direct antibacterial activity, synergize with antibiotics, and suppress bacterial virulence. The review highlights the ten most potent antibacterial flavonoids and the five most synergistic flavonoid-antibiotic combinations identified in the last six years. Panduratin A and epicatechin gallate are noted for their high minimum inhibitory concentrations (MICs) against Staphylococcus aureus and their ability to reduce oxacillin MICs, respectively. Research on improving these activities and understanding structure-activity relationships is discussed, along with proposed mechanisms of action. Flavonoids also inhibit bacterial virulence factors such as quorum sensing signal receptors, enzymes, and toxins, with evidence of these effects at the cellular level. In vivo studies show efficacy against Helicobacter pylori infection and S. aureus α-toxin intoxication. The review emphasizes the importance of further research to optimize flavonoid activity and understand their mechanisms of action, including the potential for antivirulence therapies.This review discusses recent advances in understanding the antibacterial properties of flavonoids, a family of plant-derived compounds. Flavonoids exhibit direct antibacterial activity, synergize with antibiotics, and suppress bacterial virulence. The review highlights the ten most potent antibacterial flavonoids and the five most synergistic flavonoid-antibiotic combinations identified in the last six years. Panduratin A and epicatechin gallate are noted for their high minimum inhibitory concentrations (MICs) against Staphylococcus aureus and their ability to reduce oxacillin MICs, respectively. Research on improving these activities and understanding structure-activity relationships is discussed, along with proposed mechanisms of action. Flavonoids also inhibit bacterial virulence factors such as quorum sensing signal receptors, enzymes, and toxins, with evidence of these effects at the cellular level. In vivo studies show efficacy against Helicobacter pylori infection and S. aureus α-toxin intoxication. The review emphasizes the importance of further research to optimize flavonoid activity and understand their mechanisms of action, including the potential for antivirulence therapies.