The article reviews the recent advances in CRISPR/Cas technology for enhancing staple crops, emphasizing its transformative potential in addressing global food security and sustainability challenges. CRISPR/Cas systems have emerged as revolutionary tools for precise genetic modifications in crops, offering significant advancements in resilience, yield, and nutritional value. Recent innovations such as prime and base editing, along with the development of novel CRISPR-associated proteins, have improved the specificity, efficiency, and scope of genome editing in agriculture. These advancements enable targeted genetic modifications that enhance tolerance to abiotic and biotic stresses, improve yield and quality, and address nutritional deficiencies through biofortification. The review highlights the application of CRISPR/Cas technology in enhancing crop resilience against various stresses, including drought, heat, salt, cold, heavy metals, UV radiation, and oxidative stress. It also discusses the improvement of biotic stress resistance, such as against viruses, bacteria, fungi, pests, and nematodes. Additionally, the article explores how CRISPR/Cas technology can increase crop yield and quality by targeting specific genes and pathways, including nutrient transport, photosynthetic efficiency, and biofortification. Case studies of CRISPR/Cas applications in rice and maize are provided to illustrate the technology's transformative role in enhancing resilience and productivity. Despite challenges such as off-target effects, regulatory hurdles, and efficiency issues, the review underscores the importance of CRISPR/Cas in addressing global food security and sustainability. It calls for continued research and integration of CRISPR with other emerging technologies like nanotechnology, synthetic biology, and machine learning to fully realize its potential in developing resilient, productive, and sustainable agricultural systems.The article reviews the recent advances in CRISPR/Cas technology for enhancing staple crops, emphasizing its transformative potential in addressing global food security and sustainability challenges. CRISPR/Cas systems have emerged as revolutionary tools for precise genetic modifications in crops, offering significant advancements in resilience, yield, and nutritional value. Recent innovations such as prime and base editing, along with the development of novel CRISPR-associated proteins, have improved the specificity, efficiency, and scope of genome editing in agriculture. These advancements enable targeted genetic modifications that enhance tolerance to abiotic and biotic stresses, improve yield and quality, and address nutritional deficiencies through biofortification. The review highlights the application of CRISPR/Cas technology in enhancing crop resilience against various stresses, including drought, heat, salt, cold, heavy metals, UV radiation, and oxidative stress. It also discusses the improvement of biotic stress resistance, such as against viruses, bacteria, fungi, pests, and nematodes. Additionally, the article explores how CRISPR/Cas technology can increase crop yield and quality by targeting specific genes and pathways, including nutrient transport, photosynthetic efficiency, and biofortification. Case studies of CRISPR/Cas applications in rice and maize are provided to illustrate the technology's transformative role in enhancing resilience and productivity. Despite challenges such as off-target effects, regulatory hurdles, and efficiency issues, the review underscores the importance of CRISPR/Cas in addressing global food security and sustainability. It calls for continued research and integration of CRISPR with other emerging technologies like nanotechnology, synthetic biology, and machine learning to fully realize its potential in developing resilient, productive, and sustainable agricultural systems.