The Suzuki–Miyaura (SM) cross-coupling reaction is a highly efficient method for forming carbon–carbon (C–C) bonds in organic synthesis. It is particularly effective for the synthesis of biaryls and has become a popular method due to its mild reaction conditions, the availability of boronic acids, and the ease of handling and removal of byproducts. The reaction typically involves aryl halides (bromides or iodides) and boronic acids in the presence of Pd(0) or Pd(II) catalysts. Recent developments have focused on improving catalyst efficiency, expanding the range of substrates, and using more environmentally friendly conditions. The SM reaction has been applied to the synthesis of various natural and unnatural products, including dendrimers, porphyrins, and unusual amino acids and peptides. New catalysts, such as palladacyclic complexes and nickel-based catalysts, have been developed to enhance reaction efficiency and reduce the need for phosphine ligands. Additionally, the reaction has been adapted for use in water-soluble systems and under green conditions, which are more sustainable and environmentally friendly. The SM cross-coupling reaction continues to be a valuable tool in organic synthesis due to its versatility, efficiency, and applicability to a wide range of substrates.The Suzuki–Miyaura (SM) cross-coupling reaction is a highly efficient method for forming carbon–carbon (C–C) bonds in organic synthesis. It is particularly effective for the synthesis of biaryls and has become a popular method due to its mild reaction conditions, the availability of boronic acids, and the ease of handling and removal of byproducts. The reaction typically involves aryl halides (bromides or iodides) and boronic acids in the presence of Pd(0) or Pd(II) catalysts. Recent developments have focused on improving catalyst efficiency, expanding the range of substrates, and using more environmentally friendly conditions. The SM reaction has been applied to the synthesis of various natural and unnatural products, including dendrimers, porphyrins, and unusual amino acids and peptides. New catalysts, such as palladacyclic complexes and nickel-based catalysts, have been developed to enhance reaction efficiency and reduce the need for phosphine ligands. Additionally, the reaction has been adapted for use in water-soluble systems and under green conditions, which are more sustainable and environmentally friendly. The SM cross-coupling reaction continues to be a valuable tool in organic synthesis due to its versatility, efficiency, and applicability to a wide range of substrates.