This review provides an overview of the recent progress in covalent organic frameworks (COFs) for flexible electronic devices. COFs, known for their porous structure, high crystallinity, and tunable properties, have shown great potential in various applications, including flexible energy storage devices, memristors, and sensors. The synthesis strategies of COF materials, such as powder-pressing, fabrication of COF composites, solution-processable COFs, interfacial growth, and electrochemical methods, are discussed in detail. The applications of COFs in flexible energy storage devices, such as solid-state lithium-ion batteries and supercapacitors, are highlighted, emphasizing their high energy density, cycle stability, and mechanical flexibility. In memristors, COFs exhibit excellent switching behavior, high endurance, and low power consumption, making them suitable for data storage and neuromorphic computing. For humidity sensors, COFs provide high sensitivity, selectivity, and mechanical resilience, making them ideal for real-time monitoring technologies. Despite the promising applications, challenges such as poor solubility and processability remain, and future research should focus on developing thin-film COFs with improved conductivity and integration methods to enhance device performance. The review concludes by outlining the future directions and potential of COFs in flexible electronics, emphasizing the need for further exploration and collaboration across disciplines.This review provides an overview of the recent progress in covalent organic frameworks (COFs) for flexible electronic devices. COFs, known for their porous structure, high crystallinity, and tunable properties, have shown great potential in various applications, including flexible energy storage devices, memristors, and sensors. The synthesis strategies of COF materials, such as powder-pressing, fabrication of COF composites, solution-processable COFs, interfacial growth, and electrochemical methods, are discussed in detail. The applications of COFs in flexible energy storage devices, such as solid-state lithium-ion batteries and supercapacitors, are highlighted, emphasizing their high energy density, cycle stability, and mechanical flexibility. In memristors, COFs exhibit excellent switching behavior, high endurance, and low power consumption, making them suitable for data storage and neuromorphic computing. For humidity sensors, COFs provide high sensitivity, selectivity, and mechanical resilience, making them ideal for real-time monitoring technologies. Despite the promising applications, challenges such as poor solubility and processability remain, and future research should focus on developing thin-film COFs with improved conductivity and integration methods to enhance device performance. The review concludes by outlining the future directions and potential of COFs in flexible electronics, emphasizing the need for further exploration and collaboration across disciplines.