The study identifies insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as a distinct family of N6-methyladenosine (m6A) readers that target thousands of mRNA transcripts through recognizing the consensus GG(m6A)C sequence. Unlike YTHDF2, which promotes mRNA decay, IGF2BPs enhance the stability and storage of their target mRNAs, such as *MYC*, under normal and stress conditions. The K homology (KH) domains of IGF2BPs are essential for their recognition of m6A and their oncogenic functions. The findings reveal a new role of m6A in promoting mRNA stability and translation, highlighting the importance of IGF2BPs as m6A readers in post-transcriptional gene regulation and cancer biology.The study identifies insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as a distinct family of N6-methyladenosine (m6A) readers that target thousands of mRNA transcripts through recognizing the consensus GG(m6A)C sequence. Unlike YTHDF2, which promotes mRNA decay, IGF2BPs enhance the stability and storage of their target mRNAs, such as *MYC*, under normal and stress conditions. The K homology (KH) domains of IGF2BPs are essential for their recognition of m6A and their oncogenic functions. The findings reveal a new role of m6A in promoting mRNA stability and translation, highlighting the importance of IGF2BPs as m6A readers in post-transcriptional gene regulation and cancer biology.