The study identifies IGF2BP1, IGF2BP2, and IGF2BP3 as a new family of m6A readers that recognize the GG(m6A)C sequence on mRNA, promoting mRNA stability and translation. Unlike YTHDF2, which promotes mRNA decay, IGF2BPs stabilize m6A-modified mRNAs under normal and stress conditions, thereby influencing gene expression. The KH domains of IGF2BPs are essential for m6A recognition and their oncogenic functions. The study reveals that IGF2BPs bind to m6A-modified mRNAs, including MYC, and regulate their stability and translation. IGF2BPs also play a role in mRNA storage during stress, co-localizing with stress granules. The KH3-4 domain is critical for m6A recognition and binding. IGF2BPs are involved in oncogenesis, as their knockdown reduces the expression of oncogenic transcripts like MYC. The study highlights the functional importance of IGF2BPs as m6A readers in post-transcriptional gene regulation and cancer biology. The findings suggest that IGF2BPs are essential for the regulation of m6A-modified genes and their expression in both normal and stress conditions. The study provides insights into the mechanisms by which IGF2BPs regulate mRNA stability and translation, and their role in cancer. The results demonstrate that IGF2BPs are critical for the regulation of m6A-modified genes and their expression in both normal and stress conditions. The study also shows that IGF2BPs are involved in the regulation of mRNA stability and translation, and their role in cancer. The findings highlight the importance of IGF2BPs as m6A readers in post-transcriptional gene regulation and cancer biology.The study identifies IGF2BP1, IGF2BP2, and IGF2BP3 as a new family of m6A readers that recognize the GG(m6A)C sequence on mRNA, promoting mRNA stability and translation. Unlike YTHDF2, which promotes mRNA decay, IGF2BPs stabilize m6A-modified mRNAs under normal and stress conditions, thereby influencing gene expression. The KH domains of IGF2BPs are essential for m6A recognition and their oncogenic functions. The study reveals that IGF2BPs bind to m6A-modified mRNAs, including MYC, and regulate their stability and translation. IGF2BPs also play a role in mRNA storage during stress, co-localizing with stress granules. The KH3-4 domain is critical for m6A recognition and binding. IGF2BPs are involved in oncogenesis, as their knockdown reduces the expression of oncogenic transcripts like MYC. The study highlights the functional importance of IGF2BPs as m6A readers in post-transcriptional gene regulation and cancer biology. The findings suggest that IGF2BPs are essential for the regulation of m6A-modified genes and their expression in both normal and stress conditions. The study provides insights into the mechanisms by which IGF2BPs regulate mRNA stability and translation, and their role in cancer. The results demonstrate that IGF2BPs are critical for the regulation of m6A-modified genes and their expression in both normal and stress conditions. The study also shows that IGF2BPs are involved in the regulation of mRNA stability and translation, and their role in cancer. The findings highlight the importance of IGF2BPs as m6A readers in post-transcriptional gene regulation and cancer biology.