This review article by Jiangtao Tian and Wenhan Cao provides an in-depth overview of the recent advancements in the design, fabrication, and applications of stretchable and reconfigurable metasurfaces. Metasurfaces, artificial structures composed of micro- or nano-antennas, have gained significant attention due to their unique electromagnetic properties, enabling applications in bioimaging, cancer detection, immunoassay, and on-body health monitoring systems. The flexibility and stretchability of these metasurfaces enhance their biocompatibility and wearability, while also providing unique control over structural and geometrical reconfiguration, leading to enhanced tunability for biomedical sensing and detection. The article discusses various tuning mechanisms for flexible metasurfaces, including mechanical, photoactuated, electroactuated, and magnetoactuated methods. Mechanical tuning, such as MEMS (Micro-Electro-Mechanical Systems), origami, and kirigami, allows for precise control over the deformation and reconfiguration of metasurfaces. Photoactuated tuning leverages light to manipulate material structures, while electroactuated tuning uses electrical fields to adjust the deformation. Magnetoactuated tuning exploits the sensitivity of certain materials to magnetic fields. The fabrication techniques for flexible and stretchable metasurfaces are also covered, including traditional subtractive manufacturing methods like lithography and additive manufacturing techniques such as inkjet printing, 3D printing, and soft lithography. These techniques are crucial for fabricating metasurfaces on various substrates, from rigid materials like silicon to flexible polymers like PDMS. The applications of flexible and stretchable reconfigurable metasurfaces are highlighted in several fields, particularly in bioimaging, immunoassay, and cancer detection. In bioimaging, metasurfaces improve the quality and efficiency of imaging by controlling the intensity, phase, and polarization of light. In immunoassay, they enhance sensitivity and accuracy while maintaining flexibility. In cancer detection, metasurfaces are used to design devices that can detect tumor markers with high sensitivity and specificity. The article concludes by discussing future perspectives and challenges in the development of stretchable and reconfigurable metamaterials and metasurfaces, emphasizing the potential for further advancements in flexibility, scalability, and biomedical applications.This review article by Jiangtao Tian and Wenhan Cao provides an in-depth overview of the recent advancements in the design, fabrication, and applications of stretchable and reconfigurable metasurfaces. Metasurfaces, artificial structures composed of micro- or nano-antennas, have gained significant attention due to their unique electromagnetic properties, enabling applications in bioimaging, cancer detection, immunoassay, and on-body health monitoring systems. The flexibility and stretchability of these metasurfaces enhance their biocompatibility and wearability, while also providing unique control over structural and geometrical reconfiguration, leading to enhanced tunability for biomedical sensing and detection. The article discusses various tuning mechanisms for flexible metasurfaces, including mechanical, photoactuated, electroactuated, and magnetoactuated methods. Mechanical tuning, such as MEMS (Micro-Electro-Mechanical Systems), origami, and kirigami, allows for precise control over the deformation and reconfiguration of metasurfaces. Photoactuated tuning leverages light to manipulate material structures, while electroactuated tuning uses electrical fields to adjust the deformation. Magnetoactuated tuning exploits the sensitivity of certain materials to magnetic fields. The fabrication techniques for flexible and stretchable metasurfaces are also covered, including traditional subtractive manufacturing methods like lithography and additive manufacturing techniques such as inkjet printing, 3D printing, and soft lithography. These techniques are crucial for fabricating metasurfaces on various substrates, from rigid materials like silicon to flexible polymers like PDMS. The applications of flexible and stretchable reconfigurable metasurfaces are highlighted in several fields, particularly in bioimaging, immunoassay, and cancer detection. In bioimaging, metasurfaces improve the quality and efficiency of imaging by controlling the intensity, phase, and polarization of light. In immunoassay, they enhance sensitivity and accuracy while maintaining flexibility. In cancer detection, metasurfaces are used to design devices that can detect tumor markers with high sensitivity and specificity. The article concludes by discussing future perspectives and challenges in the development of stretchable and reconfigurable metamaterials and metasurfaces, emphasizing the potential for further advancements in flexibility, scalability, and biomedical applications.