This study investigates the recruitment of brown adipose tissue (BAT) as an antiobesity agent in humans. BAT, which burns fat to produce heat, is known to decrease with age, leading to increased body fat accumulation. The researchers used fluorodeoxyglucose-positron emission tomography and computed tomography (FDG-PET/CT) to assess BAT activity and found that it correlated strongly with energy expenditure (EE) and body fat mass. Acute cold exposure at 19°C for 2 hours increased EE, and chronic daily cold exposure at 17°C for 6 weeks significantly increased BAT activity, EE, and reduced body fat mass. Similarly, daily ingestion of capsinoids (nonpungent capsaicin analogs) for 6 weeks also increased EE and BAT activity. These findings suggest that human BAT can be recruited even in individuals with low BAT activity, contributing to body fat reduction. The study provides evidence for the potential of BAT recruitment as a practical and effective antiobesity strategy.This study investigates the recruitment of brown adipose tissue (BAT) as an antiobesity agent in humans. BAT, which burns fat to produce heat, is known to decrease with age, leading to increased body fat accumulation. The researchers used fluorodeoxyglucose-positron emission tomography and computed tomography (FDG-PET/CT) to assess BAT activity and found that it correlated strongly with energy expenditure (EE) and body fat mass. Acute cold exposure at 19°C for 2 hours increased EE, and chronic daily cold exposure at 17°C for 6 weeks significantly increased BAT activity, EE, and reduced body fat mass. Similarly, daily ingestion of capsinoids (nonpungent capsaicin analogs) for 6 weeks also increased EE and BAT activity. These findings suggest that human BAT can be recruited even in individuals with low BAT activity, contributing to body fat reduction. The study provides evidence for the potential of BAT recruitment as a practical and effective antiobesity strategy.