Naringin, a natural flavonoid found in citrus fruits and herbal plants, has shown significant therapeutic potential in treating various inflammatory diseases. It exhibits anti-inflammatory, anti-apoptotic, antioxidant, and detoxifying effects, and is safe with minimal side effects, making it a promising candidate for further research. Naringin's mechanisms of action involve multiple signaling pathways, including the AMPK/Nrf2 pathway, which reduces oxidative stress and mitochondrial damage. It also modulates the Nrf2 signaling pathway to protect against drug-induced toxicity, such as that caused by acetaminophen, cyclophosphamide, methotrexate, cisplatin, and doxorubicin. Naringin has been shown to alleviate inflammation and oxidative stress in neuroinflammatory diseases like Alzheimer's and Parkinson's, and it plays a role in treating cardiovascular inflammatory diseases by reducing atherosclerosis, diabetic cardiomyopathy, and diabetic cardiac autonomic neuropathy. It also shows promise in treating inflammatory bowel diseases, inflammatory lung diseases, liver inflammation, and skin and joint inflammation. Naringin's safety profile and potential for improving bioavailability through nanocarriers make it a valuable therapeutic agent. However, further research is needed to fully understand its mechanisms and optimize its use in clinical settings.Naringin, a natural flavonoid found in citrus fruits and herbal plants, has shown significant therapeutic potential in treating various inflammatory diseases. It exhibits anti-inflammatory, anti-apoptotic, antioxidant, and detoxifying effects, and is safe with minimal side effects, making it a promising candidate for further research. Naringin's mechanisms of action involve multiple signaling pathways, including the AMPK/Nrf2 pathway, which reduces oxidative stress and mitochondrial damage. It also modulates the Nrf2 signaling pathway to protect against drug-induced toxicity, such as that caused by acetaminophen, cyclophosphamide, methotrexate, cisplatin, and doxorubicin. Naringin has been shown to alleviate inflammation and oxidative stress in neuroinflammatory diseases like Alzheimer's and Parkinson's, and it plays a role in treating cardiovascular inflammatory diseases by reducing atherosclerosis, diabetic cardiomyopathy, and diabetic cardiac autonomic neuropathy. It also shows promise in treating inflammatory bowel diseases, inflammatory lung diseases, liver inflammation, and skin and joint inflammation. Naringin's safety profile and potential for improving bioavailability through nanocarriers make it a valuable therapeutic agent. However, further research is needed to fully understand its mechanisms and optimize its use in clinical settings.