Naringin, a natural flavonoid found in citrus fruits and herbal plants, has gained attention for its potential therapeutic properties in inflammatory diseases. This review aims to elucidate the mechanism of action and therapeutic efficacy of naringin in various inflammatory conditions. Naringin has been shown to exert anti-inflammatory, anti-apoptotic, anti-oxidative stress, anti-ulcerative, and detoxifying effects. It is safe and can even alleviate the toxic side effects associated with other drugs, making it a promising candidate for treating inflammatory diseases. The review covers the chemical structure, bioavailability, pharmacological properties, and pharmacokinetics of naringin, highlighting its potential in treating neuroinflammatory diseases, cardiovascular inflammatory diseases, inflammatory bowel diseases, renal inflammation, skin inflammation, and joint inflammation. Naringin's ability to reduce oxidative stress, inflammation, and apoptosis, while promoting cell proliferation and regeneration, makes it a valuable tool in the management of inflammatory disorders. Additionally, naringin's safety profile, including its minimal toxic effects on the reproductive system and lack of significant hepatotoxicity and nephrotoxicity, further supports its potential as a therapeutic agent.Naringin, a natural flavonoid found in citrus fruits and herbal plants, has gained attention for its potential therapeutic properties in inflammatory diseases. This review aims to elucidate the mechanism of action and therapeutic efficacy of naringin in various inflammatory conditions. Naringin has been shown to exert anti-inflammatory, anti-apoptotic, anti-oxidative stress, anti-ulcerative, and detoxifying effects. It is safe and can even alleviate the toxic side effects associated with other drugs, making it a promising candidate for treating inflammatory diseases. The review covers the chemical structure, bioavailability, pharmacological properties, and pharmacokinetics of naringin, highlighting its potential in treating neuroinflammatory diseases, cardiovascular inflammatory diseases, inflammatory bowel diseases, renal inflammation, skin inflammation, and joint inflammation. Naringin's ability to reduce oxidative stress, inflammation, and apoptosis, while promoting cell proliferation and regeneration, makes it a valuable tool in the management of inflammatory disorders. Additionally, naringin's safety profile, including its minimal toxic effects on the reproductive system and lack of significant hepatotoxicity and nephrotoxicity, further supports its potential as a therapeutic agent.