This study presents a self-powered, fully implantable bone defect electrical stimulation (BD-ES) system that combines a hybrid tribo/piezoelectric nanogenerator (HTP-NG) and a conductive bioactive hydrogel to enhance bone regeneration. The HTP-NG, which does not require external circuits or batteries, converts mechanical energy from knee joint movements into biphasic electric pulses. These pulses are then transmitted to the bone defect area via the conductive hydrogel, which is composed of polydopamine-modified black phosphorus nanosheets (BP@PDA) and alginate methacryloyl (AlgMA) grafted with extracellular matrix (ECM). The system enhances multiple osteogenesis-related biological processes, including calcium ion import and osteogenic differentiation. In a rat model of critical-sized femoral defects, the BD-ES system significantly accelerated bone healing, with complete bone regeneration observed within 6 weeks. The study demonstrates the potential of this symbiotic electrical stimulation therapy for clinical applications, offering a flexible and lightweight solution for bone regeneration.This study presents a self-powered, fully implantable bone defect electrical stimulation (BD-ES) system that combines a hybrid tribo/piezoelectric nanogenerator (HTP-NG) and a conductive bioactive hydrogel to enhance bone regeneration. The HTP-NG, which does not require external circuits or batteries, converts mechanical energy from knee joint movements into biphasic electric pulses. These pulses are then transmitted to the bone defect area via the conductive hydrogel, which is composed of polydopamine-modified black phosphorus nanosheets (BP@PDA) and alginate methacryloyl (AlgMA) grafted with extracellular matrix (ECM). The system enhances multiple osteogenesis-related biological processes, including calcium ion import and osteogenic differentiation. In a rat model of critical-sized femoral defects, the BD-ES system significantly accelerated bone healing, with complete bone regeneration observed within 6 weeks. The study demonstrates the potential of this symbiotic electrical stimulation therapy for clinical applications, offering a flexible and lightweight solution for bone regeneration.