A systematic review of studies from 2016 to 2022 found a strong positive correlation between antibiotic consumption (ABC) and antibiotic resistance (ABR). The pooled ABC was 948,017.9 DPDs and 4,108.6 DIDs, with over 70% of antibiotics from the Watch and Reserve category. The average ABR prevalence was 38.4%, with Enterococcus faecium, Acinetobacter baumannii, and Pseudomonas aeruginosa being the most resistant bacteria. Cephalosporins, penicillin, and aminoglycosides were commonly involved in ABR. The review also revealed cross-resistance between different antibiotics and ABR. Optimizing antibiotic therapy and reducing unnecessary ABC can prevent the emergence and spread of ABR. Antibiotic stewardship programs (ASPs) are recommended to reduce ABC and ABR. The review highlights the need for global surveillance and implementation of ASPs to combat ABR. The study emphasizes the importance of monitoring antibiotic use and resistance to improve antibiotic use and reduce ABR. The findings suggest that reducing antibiotic overuse and misuse is crucial in preventing the development of resistant bacterial strains. The review also notes that carbapenems and fluoroquinolones are most commonly correlated with resistance rates of various bacteria. The study underscores the need for evidence-based antibiotic prescribing practices and the implementation of ASPs to address the growing threat of ABR.A systematic review of studies from 2016 to 2022 found a strong positive correlation between antibiotic consumption (ABC) and antibiotic resistance (ABR). The pooled ABC was 948,017.9 DPDs and 4,108.6 DIDs, with over 70% of antibiotics from the Watch and Reserve category. The average ABR prevalence was 38.4%, with Enterococcus faecium, Acinetobacter baumannii, and Pseudomonas aeruginosa being the most resistant bacteria. Cephalosporins, penicillin, and aminoglycosides were commonly involved in ABR. The review also revealed cross-resistance between different antibiotics and ABR. Optimizing antibiotic therapy and reducing unnecessary ABC can prevent the emergence and spread of ABR. Antibiotic stewardship programs (ASPs) are recommended to reduce ABC and ABR. The review highlights the need for global surveillance and implementation of ASPs to combat ABR. The study emphasizes the importance of monitoring antibiotic use and resistance to improve antibiotic use and reduce ABR. The findings suggest that reducing antibiotic overuse and misuse is crucial in preventing the development of resistant bacterial strains. The review also notes that carbapenems and fluoroquinolones are most commonly correlated with resistance rates of various bacteria. The study underscores the need for evidence-based antibiotic prescribing practices and the implementation of ASPs to address the growing threat of ABR.