This systematic meta-analysis examines the relationship between lipohypertrophy, glycemic control, and insulin dosing in diabetic patients. The study analyzed data from 37 studies, revealing that patients with lipohypertrophy were more likely to experience unexplained hypoglycemia, overall hypoglycemia, and glycemic variability compared to those without lipohypertrophy. They also had higher HbA1c levels and increased daily insulin consumption. These findings suggest that lipohypertrophy is associated with worse glycemic control and higher insulin use. The study highlights the importance of proper insulin injection techniques and site rotation to prevent lipohypertrophy, which can negatively impact diabetes management. The results emphasize the need for education on correct insulin injection practices to improve glycemic control and reduce insulin doses. The study also notes that lipohypertrophy may be underdiagnosed, as some cases are not easily detectable through visual or palpation methods. The research underscores the significance of routine screening and proper injection techniques in managing diabetes effectively.This systematic meta-analysis examines the relationship between lipohypertrophy, glycemic control, and insulin dosing in diabetic patients. The study analyzed data from 37 studies, revealing that patients with lipohypertrophy were more likely to experience unexplained hypoglycemia, overall hypoglycemia, and glycemic variability compared to those without lipohypertrophy. They also had higher HbA1c levels and increased daily insulin consumption. These findings suggest that lipohypertrophy is associated with worse glycemic control and higher insulin use. The study highlights the importance of proper insulin injection techniques and site rotation to prevent lipohypertrophy, which can negatively impact diabetes management. The results emphasize the need for education on correct insulin injection practices to improve glycemic control and reduce insulin doses. The study also notes that lipohypertrophy may be underdiagnosed, as some cases are not easily detectable through visual or palpation methods. The research underscores the significance of routine screening and proper injection techniques in managing diabetes effectively.