This systematic meta-analysis aimed to evaluate the relationship between lipohypertrophy and glycemic control, as well as insulin dosing in diabetic patients. The study included 37 studies with a total of 40 articles, focusing on glycemic control parameters (HbA1c, glycemic variability, uncontrolled glycemia) and insulin dosing. The results showed that patients with lipohypertrophy were more likely to experience unexplained hypoglycemia, overall hypoglycemia, and glycemic variability compared to those without lipohypertrophy. They also had higher HbA1c levels and required higher daily insulin doses. The meta-analyses indicated that lipohypertrophy is associated with poorer glycemic control and increased insulin consumption. The study highlights the importance of routine screening for lipohypertrophy and patient education on proper insulin injection techniques to improve diabetes management and prevent long-term complications.This systematic meta-analysis aimed to evaluate the relationship between lipohypertrophy and glycemic control, as well as insulin dosing in diabetic patients. The study included 37 studies with a total of 40 articles, focusing on glycemic control parameters (HbA1c, glycemic variability, uncontrolled glycemia) and insulin dosing. The results showed that patients with lipohypertrophy were more likely to experience unexplained hypoglycemia, overall hypoglycemia, and glycemic variability compared to those without lipohypertrophy. They also had higher HbA1c levels and required higher daily insulin doses. The meta-analyses indicated that lipohypertrophy is associated with poorer glycemic control and increased insulin consumption. The study highlights the importance of routine screening for lipohypertrophy and patient education on proper insulin injection techniques to improve diabetes management and prevent long-term complications.