The article "Relative Energy Deficiency in Sport (REDS): Endocrine Manifestations, Pathophysiology and Treatments" by Angeliki M. Angelidi et al. reviews the concept of Relative Energy Deficiency in Sport (REDS), which encompasses a spectrum of abnormalities induced by low energy availability (LEA) affecting both male and female athletes. The authors discuss the pathophysiology of REDS, including its impact on neuroendocrine, bone, immune, and hematological systems. They highlight the importance of leptin and the activin-Follistatin-Inhibin axis in managing symptoms and preventing health complications such as menstrual dysfunction and bone stress injuries. The article also explores current and potential treatments, emphasizing nonpharmacological, behavioral, and lifestyle modifications. The authors emphasize the need for further research to refine the definition and management of REDS, particularly in addressing gender-specific differences and long-term effects. The review underscores the complexity of REDS and the importance of a multidisciplinary approach to its management.The article "Relative Energy Deficiency in Sport (REDS): Endocrine Manifestations, Pathophysiology and Treatments" by Angeliki M. Angelidi et al. reviews the concept of Relative Energy Deficiency in Sport (REDS), which encompasses a spectrum of abnormalities induced by low energy availability (LEA) affecting both male and female athletes. The authors discuss the pathophysiology of REDS, including its impact on neuroendocrine, bone, immune, and hematological systems. They highlight the importance of leptin and the activin-Follistatin-Inhibin axis in managing symptoms and preventing health complications such as menstrual dysfunction and bone stress injuries. The article also explores current and potential treatments, emphasizing nonpharmacological, behavioral, and lifestyle modifications. The authors emphasize the need for further research to refine the definition and management of REDS, particularly in addressing gender-specific differences and long-term effects. The review underscores the complexity of REDS and the importance of a multidisciplinary approach to its management.