This study evaluates two non-conventional extraction techniques—microwave hydrodiffusion and gravity (MHG) and pressurized-liquid extraction (PLE)—for obtaining bioactive compounds from Solanum viarum, a plant rich in pyrrolizidine alkaloids. The study assessed various parameters influencing extraction yield and chemical composition. PLE yielded the highest extract (26.11 wt.%) and bioactive compound concentration, while MHG yielded 1.68 wt.%. Both methods efficiently extracted integerrimine, senecionine, and quinic acid. PLE was more efficient in extracting compounds, with higher yields and better solubility at high pressure and temperature. MHG, on the other hand, was effective in concentrating quinic acid, cytidine, and solasodine. The study highlights the potential of these techniques for future research, considering their efficiency, reduced extraction time, and lower toxicity. The results indicate that innovative extraction methods can be valuable alternatives to traditional techniques, offering higher yields and better extraction efficiency. The study also emphasizes the importance of understanding the chemical composition of plants using different extraction methods to explore their potential applications in various fields. The findings suggest that S. viarum extracts have promising applications in pharmaceutical, agricultural, and other industries due to their bioactive compounds. The study concludes that the use of green extraction technologies can be an excellent alternative to conventional methods, enabling the development of new products with diverse applications.This study evaluates two non-conventional extraction techniques—microwave hydrodiffusion and gravity (MHG) and pressurized-liquid extraction (PLE)—for obtaining bioactive compounds from Solanum viarum, a plant rich in pyrrolizidine alkaloids. The study assessed various parameters influencing extraction yield and chemical composition. PLE yielded the highest extract (26.11 wt.%) and bioactive compound concentration, while MHG yielded 1.68 wt.%. Both methods efficiently extracted integerrimine, senecionine, and quinic acid. PLE was more efficient in extracting compounds, with higher yields and better solubility at high pressure and temperature. MHG, on the other hand, was effective in concentrating quinic acid, cytidine, and solasodine. The study highlights the potential of these techniques for future research, considering their efficiency, reduced extraction time, and lower toxicity. The results indicate that innovative extraction methods can be valuable alternatives to traditional techniques, offering higher yields and better extraction efficiency. The study also emphasizes the importance of understanding the chemical composition of plants using different extraction methods to explore their potential applications in various fields. The findings suggest that S. viarum extracts have promising applications in pharmaceutical, agricultural, and other industries due to their bioactive compounds. The study concludes that the use of green extraction technologies can be an excellent alternative to conventional methods, enabling the development of new products with diverse applications.