The article discusses the challenges and issues of reproducibility in research involving metal-organic frameworks (MOFs) for nanomedicine. MOFs are widely studied for their potential in drug delivery due to their high molecular storage capacities, chemically addressable surfaces, and biocompatibility. However, reproducibility is a significant barrier in this field, influenced by batch-to-batch variations in synthesis, differences in analytical practices, and the lack of standardized protocols. The author highlights the variability in synthetic and characterization practices, using UiO-66 as a case study, and emphasizes the importance of precise characterization of key physical properties such as particle size, morphology, and surface chemistry. The article also addresses in vitro experimental reproducibility, noting issues like the complexity of drug delivery systems, "P-hacking," contamination, and the inapplicability of certain animal models. It calls for better standardization, open access to raw data, and more detailed experimental descriptions to enhance reproducibility and transparency in MOF research. The author concludes by emphasizing the need for interdisciplinary research teams and adherence to trusted research principles to drive clinical translation and realize the full potential of MOFs in medicine.The article discusses the challenges and issues of reproducibility in research involving metal-organic frameworks (MOFs) for nanomedicine. MOFs are widely studied for their potential in drug delivery due to their high molecular storage capacities, chemically addressable surfaces, and biocompatibility. However, reproducibility is a significant barrier in this field, influenced by batch-to-batch variations in synthesis, differences in analytical practices, and the lack of standardized protocols. The author highlights the variability in synthetic and characterization practices, using UiO-66 as a case study, and emphasizes the importance of precise characterization of key physical properties such as particle size, morphology, and surface chemistry. The article also addresses in vitro experimental reproducibility, noting issues like the complexity of drug delivery systems, "P-hacking," contamination, and the inapplicability of certain animal models. It calls for better standardization, open access to raw data, and more detailed experimental descriptions to enhance reproducibility and transparency in MOF research. The author concludes by emphasizing the need for interdisciplinary research teams and adherence to trusted research principles to drive clinical translation and realize the full potential of MOFs in medicine.